中国首例冷冻保存卵巢组织再移植成功病例报告。
Case report of the first successful cryopreserved ovarian tissue retransplantation in China.
作者信息
Ruan X, Du J, Korell M, Kong W, Lu D, Jin F, Li Y, Dai Y, Yin C, Yan S, Gu M, Mueck A O
机构信息
a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
b Department of Women's Health , University Women's Hospital, University of Tuebingen , Tuebingen , Germany.
出版信息
Climacteric. 2018 Dec;21(6):613-616. doi: 10.1080/13697137.2018.1514005. Epub 2018 Oct 31.
Ovarian tissue cryopreservation and retransplantation has been offered as a fertility preservation approach for over a decade. At least 130 live births have been reported after frozen-thawed ovarian tissue transplantation worldwide. The first International Fertility Protection Center in China was established in 2015. Until now no live birth has been reported. However, we are able to report the first Chinese successful retransplantation of cryopreserved ovarian tissue (September 2016) in a woman with squamous cell cervical carcinoma. Restoration of ovarian endocrine function was shown in the third month after transplantation, and after 21 months of follow-up the transplants are still active and maintaining good function. This first report of successful retransplantation represents a milestone in the field of fertility preservation in China.
卵巢组织冷冻保存及再移植作为一种生育力保存方法已应用了十多年。全球范围内，冻融卵巢组织移植后已有至少130例活产报道。中国首个国际生育力保护中心于2015年成立。截至目前，尚无活产报道。然而，我们能够报道首例中国成功再移植冷冻保存卵巢组织的病例（2016年9月），患者为一名宫颈鳞状细胞癌女性。移植后第三个月显示卵巢内分泌功能恢复，经过21个月的随访，移植组织仍活跃并保持良好功能。这例成功再移植的首例报道代表了中国生育力保存领域的一个里程碑。
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