2,3-二磷酸甘油酸的双膦酸甲酯类似物可抑制酵母磷酸甘油酸变位酶，但对小麦胚芽磷酸甘油酸变位酶无抑制作用。
The bisphosphonomethyl analogue of 2,3-bisphosphoglycerate inhibits yeast but not wheat-germ phosphoglycerate mutase.
作者信息
McAleese S M, Jutagir V, Blackburn G M, Fothergill-Gilmore L A
出版信息
Biochem J. 1987 Apr 1;243(1):301-4. doi: 10.1042/bj2430301.
Abstract
The bisphosphonomethyl analogue of 2,3-bisphosphoglycerate [4-phosphono-2-(phosphonomethyl) butanoate] was a potent competitive inhibitor of cofactor-dependent phosphoglycerate mutase from yeast, with a Ki of 0.8 mM. In contrast, the analogue did not affect the activity of cofactor-independent phosphoglycerate mutase from wheat germ. It is considered that this compound should be particularly useful for n.m.r. spectroscopic studies on the mechanism of action of cofactor-dependent phosphoglycerate mutases.
摘要
2,3-二磷酸甘油酸的双膦酰甲基类似物[4-膦酰基-2-(膦酰基甲基)丁酸]是酵母中依赖辅因子的磷酸甘油酸变位酶的一种有效竞争性抑制剂，其抑制常数Ki为0.8 mM。相比之下，该类似物不影响来自小麦胚芽的不依赖辅因子的磷酸甘油酸变位酶的活性。据认为，这种化合物对于通过核磁共振光谱研究依赖辅因子的磷酸甘油酸变位酶的作用机制应该特别有用。
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Specificity of phosphoglyceric acid mutase.磷酸甘油酸变位酶的特异性
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