a Estimatio SC , Mexico , Mexico.
b GSK, City of Knowledge , Clayton, Ancon , Panama.
Hum Vaccin Immunother. 2019;15(6):1251-1259. doi: 10.1080/21645515.2018.1540827. Epub 2018 Dec 11.
Worldwide, rotavirus infection has been a leading cause of severe diarrhea morbidity and mortality. Two rotavirus vaccines have been used in the National Immunization Program (NIP) in Mexico; two-dose from 2006 to 2011 and three-dose since 2011. This study assessed coverage (receiving at least one dose or full dose series) in eligible infants, compliance (% completing dose series and % completing series on schedule) in eligible infants vaccinated with (2010) versus (2012), using Mexican Social Security Institute data nationwide and by regions. In 2010, 80.7% received at least one dose of , 75.6% received both doses and 57.0% received both doses on schedule. In 2012, 85.7% received at least one dose of , 61.0% received all three doses and 43.2% received all three doses on schedule. More eligible infants received all doses with versus (p < 0.001). Among infants vaccinated with versus , 93.7% versus 71.1% completed full series (p < 0.001), and 75.5% versus 70.9% completed full series on schedule (p = 0.105), respectively. The full series coverage and compliance decreased in all regions with compared with . In conclusion, rotavirus vaccination has successfully reduced morbidity and mortality in children under 5 years in Mexico. This study found significant differences in full series coverage and compliance among infants and a higher proportion of completed scheduled at an earlier age in Mexico when comparing a two-dose vaccine in 2010 with a three-dose vaccine in 2012. Such differences might need to be taken into consideration to maximize NIP benefits, including early protection of the rotavirus vaccination program.
在全球范围内，轮状病毒感染是导致严重腹泻发病率和死亡率的主要原因。墨西哥国家免疫计划（NIP）使用了两种轮状病毒疫苗；从 2006 年到 2011 年使用了两剂疫苗，从 2011 年开始使用了三剂疫苗。本研究使用全国墨西哥社会保障研究所的数据评估了合格婴儿的覆盖率（至少接种一剂或完整疫苗系列），以及使用 （2010 年）和 （2012 年）接种疫苗的合格婴儿的依从性（完成疫苗系列的百分比和按时完成系列的百分比）。2010 年，80.7%的婴儿至少接种了一剂 ，75.6%的婴儿接种了两剂，57.0%的婴儿按时接种了两剂。2012 年，85.7%的婴儿至少接种了一剂 ，61.0%的婴儿接种了全部三剂，43.2%的婴儿按时接种了全部三剂。与 相比，更多的合格婴儿接种了所有疫苗（p<0.001）。与 相比，接种 疫苗的婴儿中，93.7%的婴儿完成了全部系列接种，而 71.1%的婴儿完成了全部系列接种（p<0.001），75.5%的婴儿完成了全部系列接种，而 70.9%的婴儿完成了全部系列接种（p=0.105）。与 相比，所有地区的全部系列接种覆盖率和依从率都有所下降。总之，轮状病毒疫苗接种成功地降低了墨西哥 5 岁以下儿童的发病率和死亡率。本研究发现，与 2010 年使用两剂疫苗相比，2012 年使用三剂疫苗时，婴儿的全部系列接种覆盖率和依从率存在显著差异，而且墨西哥更早地完成了全部系列接种的比例更高。在最大限度地发挥 NIP 效益时，可能需要考虑到这些差异，包括早期保护轮状病毒疫苗接种计划。
