Suhail M, Rizvi S I
Biochem Biophys Res Commun. 1987 Jul 15;146(1):179-86. doi: 10.1016/0006-291x(87)90708-x.
The red cell membrane (Na+ +K+)-ATPase activity is significantly elevated in diabetes mellitus. The osmotic fragility of diabetic red cells is also increased. In vivo insulin treatment restores the enzyme activity and the osmotic fragility to the normal level. In vitro insulin treatment of diabetic red cells was found to inhibit the further increase in its activity, but it failed to restore the activity to the normal level as in vivo. In diabetes increased Km of (Na+ +K+) ATPase for ATP was observed but Vmax remained the same. Arrhenius plot of this enzyme was also altered in diabetes.
糖尿病患者红细胞膜上的（钠+钾）-ATP酶活性显著升高。糖尿病红细胞的渗透脆性也增加。体内胰岛素治疗可使该酶活性和渗透脆性恢复到正常水平。体外胰岛素处理糖尿病红细胞可抑制其活性的进一步升高，但无法像体内治疗那样将活性恢复到正常水平。糖尿病患者中观察到（钠+钾）-ATP酶对ATP的米氏常数（Km）增加，但最大反应速度（Vmax）保持不变。糖尿病患者中该酶的阿累尼乌斯曲线也发生了改变。
