Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Neuroscience Center Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Curr Opin Neurobiol. 2019 Feb;54:155-162. doi: 10.1016/j.conb.2018.10.003. Epub 2018 Oct 25.
Plastic changes in synaptic transmission are thought to underlie learning and memory formation. However, changes in synaptic function are only meaningful in the context of stable baseline function. Accumulating evidence suggests that homeostatic signaling systems actively stabilize synaptic transmission in response to neural activity perturbation. Homeostatic mechanisms control both presynaptic and postsynaptic function. Here, we review recent advances in the field of presynaptic homeostatic plasticity (PHP). We discuss PHP in the context of basic mechanisms controlling neurotransmitter release, highlight emerging similarities between different synapses in different species, and summarize new insights into the molecular mechanisms underlying this evolutionary conserved form of synaptic plasticity.
突触传递的可塑性变化被认为是学习和记忆形成的基础。然而，突触功能的变化只有在稳定的基线功能的背景下才有意义。越来越多的证据表明，内稳态信号系统在神经活动扰动时积极稳定突触传递。内稳态机制控制着突触前和突触后的功能。在这里，我们回顾了突触前内稳态可塑性（PHP）领域的最新进展。我们在控制神经递质释放的基本机制的背景下讨论 PHP，强调不同物种不同突触之间的新兴相似性，并总结这种进化保守的突触可塑性的分子机制的新见解。
