多发性硬化症患者外周血中活化淋巴细胞的测定。
Determination of activated lymphocytes in peripheral blood of patients with multiple sclerosis.
作者信息
Crockard A D, McNeill T A, McKirgan J, Hawkins S A
机构信息
Department of Microbiology and Immunobiology, Queen's University of Belfast, Royal Victoria Hospital, Northern Ireland.
出版信息
J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):139-41. doi: 10.1136/jnnp.51.1.139.
Using monoclonal antibodies Ta1 and CD25 (interleukin-2 receptor: I-2R) and flow cytometry, the levels of activated lymphocytes in the peripheral blood of 50 patients with multiple sclerosis (16 relapsing inactive; 14 relapsing active; 20 chronic progressive) and 20 normal subjects were investigated. No significant differences were observed in the percentage or absolute numbers of Ta1 and IL-2R reactive lymphocytes between the normal and multiple sclerosis patient groups, irrespective of disease activity. Monitoring peripheral blood lymphocytes with respect to these markers would appear to have little value in the management of multiple sclerosis.
运用单克隆抗体Ta1和CD25（白细胞介素-2受体：I-2R）以及流式细胞术，对50例多发性硬化患者（16例复发缓解期非活动型；14例复发缓解期活动型；20例慢性进展型）和20名正常受试者外周血中活化淋巴细胞的水平进行了研究。无论疾病活动状态如何，正常组与多发性硬化患者组之间Ta1和IL-2R反应性淋巴细胞的百分比或绝对数量均未观察到显著差异。针对这些标志物监测外周血淋巴细胞，在多发性硬化的管理中似乎价值不大。
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