Gauthier Donald R, Rivera Nelo R, Yang Haifeng, Schultz Danielle M, Shultz C Scott
Department of Process Research and Development , Merck & Co., Inc. , Rahway , New Jersey 07065 , United States.
J Am Chem Soc. 2018 Nov 21;140(46):15596-15600. doi: 10.1021/jacs.8b09808. Epub 2018 Nov 8.
An operationally simple protocol for a palladium-catalyzed CO and CO exchange with activated aliphatic and benzoic carbonyls is presented. Several C and C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.
本文介绍了一种操作简单的钯催化的一氧化碳与活性脂肪族和苯甲酸羰基进行一氧化碳交换的方法。已经制备了几种碳-碳结构单元、天然产物衍生物和药物，以展示后期碳同位素掺入方法及其官能团兼容性。
