Pamecha Yash, Shelke Umesh, Patil Bhushan, Patwardhan Sujata, Kini Siddharth
Department of Urology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
Urol Ann. 2018 Oct-Dec;10(4):369-374. doi: 10.4103/UA.UA_5_18.
Defect in ureteral continuity can be due to various etiologies. The surgical options for management of complex long-segment ureteric defects are limited. Use of ileum is indicated in these cases; however, the technique is challenging and outcomes need to be assessed in detail.
It is an observational study conducted over 4 years. After preoperative optimization, ureteric reconstruction was performed using standard techniques of ileal interposition in cases of unilateral and bilateral long-segment ureteric defects. Patients were followed up at regular interval to assess outcomes and see for complications.
A total of 14 patients were studied. Two most common indications for performing ileal ureter were iatrogenic injury and radiation-induced strictures (5-5 cases). Most common site of ureteric involvement was lower and midureter seen in 6 cases. The mean length of the ileum used was 11.2 cm. Mean preoperative nadir creatinine level was 1.57 mg/dL in this study. Average postoperative creatinine level at 4-week follow-up was 1.75 mg/dL and 1.45 mg/dL and 1.37 mg/dL, at 3 and 12 months, respectively. The most common short-term complication was paralytic ileus and long-term complication was recurrent urinary tract infection UTI. There was no mortality.
Ileal ureter is found to be relatively easy and safe surgery even in patients with borderline high creatinine. There was no worsening of renal function attributable to the conduit in this study. In patients with limited surgical options, it is a suitable alternative, rather than keeping patient on permanent percutaneous nephrostomy or regular stent change. Metabolic acidosis and mucous-associated complications such as pain, infection, and stone formation can be minimized by adherence to strict protocol.
输尿管连续性缺陷可能由多种病因引起。复杂长段输尿管缺损的手术治疗选择有限。在这些情况下,可采用回肠替代;然而,该技术具有挑战性,需要详细评估其疗效。
这是一项为期4年的观察性研究。术前优化后,对于单侧和双侧长段输尿管缺损病例,采用标准的回肠代输尿管技术进行输尿管重建。定期对患者进行随访,以评估疗效并观察并发症。
共研究了14例患者。进行回肠代输尿管术的两个最常见指征是医源性损伤和放射性狭窄(各5例)。输尿管受累最常见的部位是输尿管中下段,共6例。所用回肠的平均长度为11.2厘米。本研究中患者术前肌酐水平最低点的平均值为1.57毫克/分升。术后4周随访时肌酐水平的平均值为1.75毫克/分升,3个月和12个月时分别为1.45毫克/分升和1.37毫克/分升。最常见的短期并发症是麻痹性肠梗阻,长期并发症是复发性尿路感染。无死亡病例。
即使对于肌酐水平临界升高的患者,回肠代输尿管术也相对简单且安全。本研究中未发现肾功能因输尿管替代物而恶化。对于手术选择有限的患者,这是一种合适的替代方法,而不是让患者长期进行经皮肾造瘘或定期更换支架。通过严格遵守方案,可将代谢性酸中毒和与黏液相关的并发症(如疼痛、感染和结石形成)降至最低。