van der Ende-van Loon Mirjam Cm, Rosmolen Wilda D, Houterman Saskia, Schoon Erik J, Curvers Wouter L
Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
United European Gastroenterol J. 2018 Nov;6(9):1316-1322. doi: 10.1177/2050640618798508. Epub 2018 Sep 7.
Barrett's oesophagus affects patients' quality of life and may be a psychological burden due to the threat of developing an oesophageal adenocarcinoma.
Assessing the oesophageal adenocarcinoma risk perceived by non-dysplastic Barrett's oesophagus patients and its association with quality of life, illness perception and reflux symptoms.
This cross-sectional questionnaire study included 158 Barrett's oesophagus non-dysplastic patients aged 18-75 years. Based on their annual and lifetime oesophageal adenocarcinoma risk estimations measured with the Magnifier Scale, patients were classified as overestimating or underestimating. Associations between the groups where assed on demographics, reflux symptoms and results of the Outcomes Study Short-Form-36 (SF-36) and the Brief Illness Perception Questionnaire (B-IPQ).
The annual oesophageal adenocarcinoma risk was overestimated by 41%. Overestimating patients had lower means on the SF-36 domains: bodily pain (annual = 0.007 and lifetime = 0.014), general health (annual 0.011 and lifetime = 0.014), vitality (annual = 0.030), physical functioning (lifetime = 0.028), worse illness perception (total score = 0.001) and significantly more reflux symptoms.
Overestimation of the oesophageal adenocarcinoma risk by Barrett's oesophagus patients was associated with decreased quality of life and worse illness perceptions, which is most likely caused by symptoms of dyspepsia and reflux. These symptoms should be adequately treated, and patients may be in need of extra support and specific information about their oesophageal adenocarcinoma risk.
巴雷特食管会影响患者的生活质量，且由于存在发展为食管腺癌的风险，可能会给患者带来心理负担。
评估无发育异常的巴雷特食管患者所感知到的食管腺癌风险及其与生活质量、疾病认知和反流症状的关联。
这项横断面问卷调查研究纳入了158名年龄在18至75岁之间的无发育异常的巴雷特食管患者。根据用放大镜量表测量的年度和终生食管腺癌风险估计值，将患者分为高估组或低估组。在人口统计学、反流症状以及简短健康调查量表36项简表（SF-36）和简短疾病认知问卷（B-IPQ）的结果基础上，对两组之间的关联进行评估。
41%的患者高估了年度食管腺癌风险。高估组患者在SF-36各领域的得分较低：身体疼痛（年度=0.007，终生=0.014）、总体健康状况（年度=0.011，终生=0.014）、活力（年度=0.030）、身体功能（终生=0.028）、疾病认知较差（总分=0.001），且反流症状明显更多。
巴雷特食管患者高估食管腺癌风险与生活质量下降和疾病认知较差有关，这很可能是由消化不良和反流症状引起的。应充分治疗这些症状，患者可能需要额外的支持以及关于其食管腺癌风险的具体信息。
