Lee Shou-Wu, Lien Han-Chung, Chang Chi-Sen, Ko Chung-Wang, Tung Chun-Fang, Yeh Hong-Zen
Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Internal Medicine, Chung Shan Medical University, Taichung, Taiwan.
PLoS One. 2017 Dec 21;12(12):e0190201. doi: 10.1371/journal.pone.0190201. eCollection 2017.
The aim of this study was to investigate health-related quality of life (HRQoL) of a Chinese population with Barrett's esophagus (BE).
Data from subjects with BE from a single hospital were prospectively collected from October 2012 to December 2014. The exclusion criteria included total esophagectomy, severe cardiopulmonary deficiency, malignancy, or other unsuitable conditions for scope. All the enrolled cases were asked to complete the Reflux Disease Questionnaire (RDQ), the short form-12, (SF-12), and the Hospital Anxiety and Depression Scale (HADS).
In total, 139 subjects were enrolled, and the mean age of the cases was 61.85 years old. Most subjects had short-segment BE (SSBE) (92.8%) and non-dysplastic BE tissue (94.2%). The mean physical and mental composite scores, PCS and MCS, of SF-12 were 44.14 and 45.53, respectively. The SF-12 scores in BE individuals were similar in men and women, elderly and non-elderly, LSBE and SSBE, coexisting EE and no-EE, and dysplastic and non-dysplastic. The appearance of reflux symptoms tended to decrease SF-12 scores in affected individuals, especially heartburn. The rates of anxiety and depression accounted for 25.2% and 17.3% of these cases, respectively.
Our study found HRQoL in BE patients was strongly associated with presentation of reflux symptoms.
本研究旨在调查中国巴雷特食管（BE）患者的健康相关生活质量（HRQoL）。
前瞻性收集2012年10月至2014年12月来自一家医院的BE患者数据。排除标准包括全食管切除术、严重心肺功能不全、恶性肿瘤或其他不适合内镜检查的情况。所有纳入病例均被要求完成反流病问卷（RDQ）、简短健康调查量表（SF-12）和医院焦虑抑郁量表（HADS）。
共纳入139例受试者，病例的平均年龄为61.85岁。大多数受试者为短段BE（SSBE）（92.8%）且BE组织无发育异常（94.2%）。SF-12的平均生理和心理综合评分，即PCS和MCS，分别为44.14和45.53。BE患者的SF-12评分在男性和女性、老年人和非老年人、长段BE和短段BE、合并反流性食管炎（EE）和未合并EE、发育异常和未发育异常的患者中相似。反流症状的出现往往会降低受影响个体的SF-12评分，尤其是烧心症状。焦虑和抑郁发生率分别占这些病例的25.2%和17.3%。
我们的研究发现BE患者的HRQoL与反流症状的表现密切相关。
