Barraco R A, Marcantonio D R, Phillis J W, Campbell W R
Gen Pharmacol. 1987;18(4):405-16. doi: 10.1016/0306-3623(87)90099-1.
The dose-response effects of adenosine and its analogs on cardiovascular parameters were examined in rats following intravenous administration. 5'-N-ethylcarboxamidoadenosine (NECA) was by far the most potent analog in reducing mean arterial blood (PA) pressure while N6-(3-pentyl)-adenosine exerted the most potent bradycardic action. The N6-substituted (S)-diastereoisomers were substantially less potent in reducing PA and heart rate than NECA and the N6-substituted (R)-diastereoisomers. The cardiovascular effects of adenosine analogs persist, to varying degrees, much longer than those of adenosine itself.
静脉注射后，在大鼠中研究了腺苷及其类似物对心血管参数的剂量反应效应。5'-N-乙基羧酰胺腺苷（NECA）是降低平均动脉血压方面最有效的类似物，而N6-(3-戊基)-腺苷发挥的心动过缓作用最强。N6-取代的(S)-非对映异构体在降低平均动脉血压和心率方面的效力远低于NECA和N6-取代的(R)-非对映异构体。腺苷类似物的心血管效应在不同程度上比腺苷本身持续的时间长得多。
