Nanosafety & Nanomedicine Laboratory, Institute of Environmental Medicine , Karolinska Institutet , 17777 Stockholm , Sweden.
Nanomedicine Laboratory, Faculty of Biology, Medicine & Health , University of Manchester , Manchester M13 9PL , United Kingdom.
ACS Nano. 2018 Nov 27;12(11):10582-10620. doi: 10.1021/acsnano.8b04758. Epub 2018 Nov 12.
Graphene and its derivatives are heralded as "miracle" materials with manifold applications in different sectors of society from electronics to energy storage to medicine. The increasing exploitation of graphene-based materials (GBMs) necessitates a comprehensive evaluation of the potential impact of these materials on human health and the environment. Here, we discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBMs using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that we disentangle the structure-activity relationships for this class of materials.
石墨烯及其衍生物被誉为“奇迹”材料，在从电子到能源存储再到医学的社会各个领域都有广泛的应用。基于石墨烯的材料（GBMs）的开发利用日益增加，因此需要全面评估这些材料对人类健康和环境的潜在影响。在这里，我们讨论了 GBMs 的合成和表征，以及使用体外和体内模型系统对 GBMs 的人类和环境危害评估，目的是了解这些材料的生物学效应所依据的特性；并非所有 GBMs 都是一样的，我们必须理清这类材料的结构-活性关系。
