Rana Niket, Narang Jasjeet, Chauhan Arjun
Department of Biotechnology, Panjab University, Sector 25, Chandigarh, 160014 India.
University Institute of Biotechnology, Chandigarh University, Punjab, 140413 India.
Indian J Microbiol. 2025 Mar;65(1):453-476. doi: 10.1007/s12088-024-01318-2. Epub 2024 Jul 6.
Graphene and its derivatives have excellent electrical, mechanical, and optical capabilities, making it the perfect foundation for sensing living things. Graphene-based nano biosensors have shown exceptional sensitivity, selectivity, and quick response times when used to detect a range of analytes, such as biomolecules, cells, and pathogens. The main uses of graphene-based nano biosensors are disease diagnosis, environmental monitoring, food safety, and drug development. It also explores prospective future strategies, such as methods for functionalizing nanomaterials, their incorporation with other nanomaterials, and the creation of wearable and implantable gadgets. Various signalling techniques, such as fluorescence, electrochemistry, surface plasmon resonance, surface-enhanced Raman scattering, etc., can be coupled with graphene-based biosensors to quantitatively detect disease-associated DNA, RNA, and protein biomarkers quantitatively. Graphene-based nano biosensors, combined with cutting-edge innovations like artificial intelligence and the Internet of Things, can completely transform industries like healthcare and environmental monitoring. Developing these biosensors with high sensitivity and low detection limits provides a new direction in medical and personal care. The later portion of the review covers the difficulties, prospective fixes, and opportunities of graphene-based biosensors.
石墨烯及其衍生物具有出色的电学、机械和光学性能,使其成为传感生物的理想基础。基于石墨烯的纳米生物传感器在用于检测一系列分析物(如生物分子、细胞和病原体)时,表现出了卓越的灵敏度、选择性和快速响应时间。基于石墨烯的纳米生物传感器的主要用途包括疾病诊断、环境监测、食品安全和药物开发。它还探索了未来的潜在策略,如纳米材料功能化方法、它们与其他纳米材料的结合以及可穿戴和可植入设备的创建。各种信号技术,如荧光、电化学、表面等离子体共振、表面增强拉曼散射等,可与基于石墨烯的生物传感器相结合,以定量检测与疾病相关的DNA、RNA和蛋白质生物标志物。基于石墨烯的纳米生物传感器与人工智能和物联网等前沿创新相结合,可以彻底改变医疗保健和环境监测等行业。开发具有高灵敏度和低检测限的这些生物传感器为医疗和个人护理提供了新方向。综述的后半部分涵盖了基于石墨烯的生物传感器的困难、潜在解决方案和机遇。