Kim Oh Yoen, Song Juhyun
Department of Food Science and Nutrition, Dong A University, Busan 49315, Korea.
J Clin Med. 2018 Nov 1;7(11):407. doi: 10.3390/jcm7110407.
Alzheimer's disease (AD) is characterized by progressive memory dysfunction, oxidative stress, and presence of senile plaques formed by amyloid beta (A β ) accumulation in the brain. AD is one of the most important causes of morbidity and mortality worldwide. AD has a variety of risk factors, including environmental factors, metabolic dysfunction, and genetic background. Recent research has highlighted the relationship between AD and systemic metabolic changes such as glucose and lipid imbalance and insulin resistance. Irisin, a myokine closely linked to exercise, has been associated with glucose metabolism, insulin sensitivity, and fat browning. Recent studies have suggested that irisin is involved in the process in central nervous system (CNS) such as neurogenesis and has reported the effects of irisin on AD as one of the neurodegenerative disease. Here, we review the roles of irisin with respect to AD and suggest that irisin highlight therapeutic important roles in AD. Thus, we propose that irisin could be a potential future target for ameliorating AD pathology and preventing AD onset.
阿尔茨海默病（AD）的特征是进行性记忆功能障碍、氧化应激以及大脑中由β-淀粉样蛋白（Aβ）积累形成的老年斑。AD是全球发病和死亡的最重要原因之一。AD有多种风险因素，包括环境因素、代谢功能障碍和遗传背景。最近的研究突出了AD与全身代谢变化之间的关系，如葡萄糖和脂质失衡以及胰岛素抵抗。鸢尾素是一种与运动密切相关的肌动蛋白，与葡萄糖代谢、胰岛素敏感性和脂肪褐变有关。最近的研究表明，鸢尾素参与中枢神经系统（CNS）的神经发生等过程，并报道了鸢尾素作为神经退行性疾病之一对AD的影响。在此，我们综述了鸢尾素在AD方面的作用，并表明鸢尾素在AD中具有重要的治疗作用。因此，我们提出鸢尾素可能是未来改善AD病理和预防AD发病的潜在靶点。
