Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Nutrients. 2018 Nov 1;10(11):1605. doi: 10.3390/nu10111605.
Redox homeostasis may be defined as the dynamic equilibrium between electrophiles and nucleophiles to maintain the optimum redox steady state. This mechanism involves complex reactions, including nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, activated by oxidative stress in order to restore the redox balance. The ability to maintain the optimal redox homeostasis is fundamental for preserving physiological functions and preventing phenotypic shift toward pathological conditions. Here, we reviewed mechanisms involved in redox homeostasis and how certain natural compounds regulate the nucleophilic tone. In addition, we focused on the antioxidant properties of rice and particularly on its bioactive compound, γ-oryzanol. It is well known that γ-oryzanol exerts a variety of beneficial effects mediated by its antioxidant properties. Recently, γ-oryzanol was also found as a Nrf2 inducer, resulting in nucleophilic tone regulation and making rice a para-hormetic food.
氧化还原稳态可以定义为为维持最佳氧化还原稳态而在亲电体和亲核体之间保持的动态平衡。该机制涉及复杂的反应，包括核因子红细胞 2 相关因子 2 (Nrf2) 途径，由氧化应激激活，以恢复氧化还原平衡。维持最佳氧化还原稳态的能力对于维持生理功能和防止表型向病理条件转变至关重要。在这里，我们综述了氧化还原稳态的机制，以及某些天然化合物如何调节亲核性。此外，我们还重点研究了大米的抗氧化特性，特别是其生物活性化合物——γ-谷维素。众所周知，γ-谷维素通过其抗氧化特性发挥多种有益作用。最近，γ-谷维素也被发现为 Nrf2 诱导剂，从而调节亲核性，使大米成为一种拟激素食物。
