Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.
National Development Institute of Korean Medicine, Gyeongsan, Gyeongsangbuk-do 38540, Korea.
Int J Mol Sci. 2018 Nov 1;19(11):3432. doi: 10.3390/ijms19113432.
Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional neurons and glial cells. The disruption in NSC homeostasis and/or the impaired neurogenesis lead to diverse neurological diseases, including depression, dementia, and neurodegenerative disorders. Falcarindiol (FAD) is a polyacetylene found in many plants, and FAD shows the cytotoxicity against breast cancers and colon cancers. However, there is no research on the consequence of FAD treatment in normal stem cells. Here, we suggest that FAD has anticancer roles against glioblastoma cells by inducing the differentiation of glioblastoma stem-like cells, as well as activating apoptosis pathway in glioblastoma cells. On the other hand, we also show that FAD has detrimental effects by disrupting the maintenance of normal NSCs and altering the balance between self-renewal and differentiation of NSCs.
神经干细胞（NSCs）是未分化的、多能的细胞，可以产生功能性神经元和神经胶质细胞。NSC 内稳态的破坏和/或神经发生受损导致多种神经疾病，包括抑郁症、痴呆和神经退行性疾病。法卡林二醇（FAD）是一种存在于许多植物中的多炔，FAD 对乳腺癌和结肠癌具有细胞毒性。然而，目前还没有关于 FAD 处理正常干细胞后果的研究。在这里，我们提出 FAD 通过诱导神经母细胞瘤干细胞样细胞的分化以及激活神经母细胞瘤细胞中的凋亡途径，对神经母细胞瘤细胞具有抗癌作用。另一方面，我们还表明，FAD 通过破坏正常 NSCs 的维持和改变 NSCs 的自我更新和分化之间的平衡，产生有害影响。
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