Department of Gastrointestinal Surgery, First Hospital of Jilin University, 71 Xinmin Street, Chaoyang District, Changchun, 130021, China.
Clin Transl Oncol. 2019 May;21(5):674-686. doi: 10.1007/s12094-018-1970-9. Epub 2018 Nov 3.
Programmed death-ligand 1 (PD-L1) is reportedly expressed in colorectal tumors. However, the prognostic role of PD-L1 in colorectal cancer (CRC) remains controversial. Therefore, we performed a meta-analysis to investigate the clinicopathological and prognostic impact of PD-L1 in CRC.
A comprehensive search in PubMed, Embase, the Cochrane Library, Web of Science and the ClinicalTrials.gov for publications about PD-L1 expression in colorectal cancer was done. The correlation between PD-L1 expression and clinicopathological features or survival outcomes was analyzed by odds ratios (OR) or hazard ratios (HR), at 95% confidence intervals (CI).
The results show that the pooled HR of (1.34, 95% CI 1.02-1.65, p = 0.01) indicated the association of PD-L1 expression with overall survival (OS) in CRC patients. Meanwhile, the expression of PD-L1 was positively correlated with the lymph node metastasis (OR: 0.70, 95% CI 0.51-0.95, p = 0.00), gender (OR: 0.86, 95% CI 0.76-0.98, p = 0.05) and tumor location (OR: 1.39, 95% CI 1.14-1.71, p = 0.12).
These results suggest that high expression of PD-L1 is associated with low OS in CRC. High PD-L1 expression may act as a negative factor for patients with CRC and help to identify patients suitable for anticancer therapy.
程序性死亡配体 1（PD-L1）据报道在结直肠肿瘤中表达。然而，PD-L1 在结直肠癌（CRC）中的预后作用仍存在争议。因此，我们进行了一项荟萃分析，以研究 PD-L1 在 CRC 中的临床病理和预后影响。
在 PubMed、Embase、Cochrane 图书馆、Web of Science 和 ClinicalTrials.gov 中对关于结直肠癌细胞中 PD-L1 表达的出版物进行了全面检索。通过比值比（OR）或风险比（HR），在 95%置信区间（CI）内分析 PD-L1 表达与临床病理特征或生存结局的相关性。
结果表明，PD-L1 表达与 CRC 患者总生存（OS）相关的合并 HR 为（1.34，95%CI 1.02-1.65，p=0.01）。同时，PD-L1 的表达与淋巴结转移（OR：0.70，95%CI 0.51-0.95，p=0.00）、性别（OR：0.86，95%CI 0.76-0.98，p=0.05）和肿瘤位置（OR：1.39，95%CI 1.14-1.71，p=0.12）呈正相关。
这些结果表明，CRC 中 PD-L1 的高表达与 OS 降低相关。高 PD-L1 表达可能是 CRC 患者的一个负面因素，并有助于识别适合抗癌治疗的患者。
