Neag Teodora, Olah Neli-Kinga, Hanganu Daniela, Benedec Daniela, Pripon Flavia Furtuna, Ardelean Aurel, Toma Claudia Crina
Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania.
Vasile Goldiș Western University of Arad, Faculty of Pharmacy, 86 L. Rebreanu St., Arad, Romania / SC PlantExtrakt SRL, Radaia, Cluj, Romania.
Pak J Pharm Sci. 2018 Sep;31(5(Supplementary)):2027-2032.
The Ranunculus species are poorly known as medicinal plants. They have potential toxicity given by the ranunculin and its enzymatic degradation compounds: protoanemonin and anemonin. This paper aims to evaluate the anemonin content of four species: R. bulbosus, R. ficaria, R. sardous and R. sceleratus. The evaluation was performed by TLC and HPLC. There were evaluated two types of extracts hydroalcoholic (HA) and glycerol-ethanol (GE). The most concentrated extract in anemonin was found to be the R. sardous aerial part HA extract: 2.66 mg/ml. The lowest anemonin content is in R. sceleratus: 0.13-0.19 mg/ml. In R. bulbosus aerial part the anemonin content is less than the used HPLC method detection limits (7.68 mg/ml). In all cases the GE extracts are less concentrated in anemonin, being more safely for human administration.
毛茛属植物作为药用植物鲜为人知。它们因含毛茛苷及其酶解产物原白头翁素和白头翁素而具有潜在毒性。本文旨在评估四种毛茛属植物：球根毛茛、扬子毛茛、 Sardous毛茛和石龙芮中白头翁素的含量。评估采用薄层色谱法（TLC）和高效液相色谱法（HPLC）进行。对两种提取物进行了评估，即水醇提取物（HA）和甘油 - 乙醇提取物（GE）。发现白头翁素含量最高的提取物是Sardous毛茛地上部分的HA提取物：2.66毫克/毫升。石龙芮中白头翁素含量最低：0.13 - 0.19毫克/毫升。球根毛茛地上部分的白头翁素含量低于所用高效液相色谱法的检测限（7.68毫克/毫升）。在所有情况下，GE提取物中白头翁素的浓度较低，对人体给药更安全。
