负调控作用有助于免疫球蛋白重链增强子的组织特异性。
Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.
作者信息
Imler J L, Lemaire C, Wasylyk C, Wasylyk B
出版信息
Mol Cell Biol. 1987 Jul;7(7):2558-67. doi: 10.1128/mcb.7.7.2558-2567.1987.
Abstract
We have identified in and around the immunoglobulin heavy-chain enhancer two apparently distinct negative regulatory elements which repress immunoglobulin H enhancer, simian virus 40 enhancer, and heterologous promoter activity in fibroblasts but not in myeloma cells. We propose that in nonlymphoid cells, negative regulatory elements prevent activation of the immunoglobulin H enhancer by ubiquitous stimulatory trans-acting factors.
摘要
我们在免疫球蛋白重链增强子及其周围鉴定出两个明显不同的负调控元件，它们可抑制成纤维细胞中免疫球蛋白H增强子、猿猴病毒40增强子及异源启动子的活性，但在骨髓瘤细胞中则无此作用。我们提出，在非淋巴细胞中，负调控元件可通过普遍存在的刺激性反式作用因子来阻止免疫球蛋白H增强子的激活。
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