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复发性流产的现代管理

Modern management of recurrent miscarriage.

作者信息

Homer Hayden Anthony

机构信息

Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.

Reproductive Endocrinology & Infertility Clinic, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.

出版信息

Aust N Z J Obstet Gynaecol. 2019 Feb;59(1):36-44. doi: 10.1111/ajo.12920. Epub 2018 Nov 4.

Abstract

Recurrent miscarriage (RM), also known as recurrent pregnancy loss, is a distressing condition affecting around 1% of couples trying to conceive It can be very frustrating for both clinicians and patients as, despite intensive workup, no clear underlying pathology is forthcoming in at least 50% of couples. This leads to despair for patients and leaves clinicians at a loss for how to help. Desperation in both camps can promote the uptake of investigations and interventions of unproven benefit. The pathophysiology underpinning RM is incredibly diverse, involving areas such as haematology, endocrinology, immunology and genetics. During the seven to eight years since the UK Royal College of Obstetricians and Gynaecologists published guidelines on this topic in 2011, new evidence and guidance from expert authorities have emerged. Here, these important advances in this challenging field of clinical practice will be reviewed.

摘要

复发性流产(RM),也称为复发性妊娠丢失,是一种令人苦恼的病症,影响着约1%试图受孕的夫妇。这对临床医生和患者来说都可能非常令人沮丧,因为尽管进行了深入检查,但至少50%的夫妇仍未发现明确的潜在病理原因。这导致患者绝望,也让临床医生不知如何提供帮助。双方的绝望情绪可能会促使人们采用未经证实有益的检查和干预措施。RM的病理生理学极其多样,涉及血液学、内分泌学、免疫学和遗传学等领域。自英国皇家妇产科医师学院于2011年发布关于该主题的指南以来的七到八年里,专家权威机构出现了新的证据和指导意见。在此,将对这一具有挑战性的临床实践领域的这些重要进展进行综述。

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