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诺氏疟原虫裂殖子侵入红细胞研究的最新进展

Recent advances in understanding the invasion of erythrocytes by merozoites of Plasmodium knowlesi.

作者信息

Bannister L H, Butcher G A, Mitchell G H

出版信息

Bull World Health Organ. 1977;55(2-3):163-9.

PMID:303947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366744/
Abstract

Previous observations on the process of invasion by P. knowlesi are briefly reviewed and new findings concerning the adhesion of parasites to erythrocytes and their intracellular passage are reported. Merozoites adhere to erythrocytes by means of a well-defined coat with the cytochemical characteristics of glycoprotein. This coat has receptors that engage in at least three distinct types of attachment. The ensuing invagination of the erythrocyte surface has two phases, the first consisting of an inward buckling of the membrane to form a vacuole and the second a rapid expansion to create the final parasitophorous vacuole inhabited by the trophic parasite. Some cytochemical evidence concerning the nature of the rhoptry complex is discussed in relation to these changes.

摘要

本文简要回顾了先前对诺氏疟原虫入侵过程的观察,并报告了有关寄生虫与红细胞粘附及其细胞内穿行的新发现。裂殖子通过具有糖蛋白细胞化学特征的明确被膜粘附于红细胞。该被膜具有参与至少三种不同类型附着的受体。随后红细胞表面的内陷有两个阶段,第一阶段是膜向内弯曲形成液泡,第二阶段是快速扩张以形成滋养寄生虫居住的最终的寄生泡。结合这些变化讨论了一些关于棒状体复合体性质的细胞化学证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b65f/2366744/bcbf8477d84b/bullwho00446-0044-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b65f/2366744/27e0101a50df/bullwho00446-0045-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b65f/2366744/229288498e17/bullwho00446-0045-d.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b65f/2366744/3ae3c2c890ad/bullwho00446-0044-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b65f/2366744/bcbf8477d84b/bullwho00446-0044-d.jpg

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