School of Health Sciences, Catholic University of Salta, Argentina.
Hospital Quirónsalud Bizkaia, Bilbao, Spain.
Curr Opin Allergy Clin Immunol. 2019 Feb;19(1):75-80. doi: 10.1097/ACI.0000000000000491.
Evidence-based medicine and guidelines directing the diagnosis and treatment of patients are changing. General recommendations are moving towards an individual focus, where technology evolution allows identification of specific patterns and where 'one size fits all' no longer has a place.
Emerging innovations on health technology include useful tools for individualizing patients' specific conditions and follow-up. There are several preventive initiatives that aim to reduce allergic disease development, but they have no generalizable and definitive results as yet. Both omics and molecular diagnosis have provided the basis for differentiating clusters of patients, both allowing prediction of severity and also indicating appropriate management. Here we discuss examples contributing to some specific conditions we are now facing.
Precision medicine encompasses a personalized care of the patient, the prediction of a successful treatment, the potential prevention of a disease and its progression when present and the important active participation of the patient in the planning and guidance of the approach and management. Technology and medical innovations like omics and molecular diagnosis help for discriminating specific phenotypes/endotypes and the correct individualized interventions. The great challenge for implementing precision medicine will be the possibility of providing those advances to everyone at affordable costs.
Technology and innovations in medicine are aimed to help all patients globally, providing evidence for particular conditions that need to be personally considered, involving the patient's decision while treating, predicting and preventing disease. Our aim should be to have precision medicine available everywhere at any time.
循证医学和指导患者诊断和治疗的指南正在发生变化。一般建议正朝着关注个体的方向发展,在这个方向上,技术的发展使得能够识别特定的模式,而“一刀切”的方法不再适用。
健康技术的新兴创新包括用于确定患者具体情况和后续治疗的有用工具。有几项预防措施旨在减少过敏疾病的发生,但目前还没有普遍和明确的结果。组学和分子诊断都为区分患者群体提供了基础,既能预测严重程度,也能指示适当的治疗方法。在这里,我们讨论了一些有助于我们目前面临的一些具体情况的例子。
精准医学包含了对患者的个性化护理、预测成功的治疗效果、在疾病存在时预防其进展的潜力,以及患者在规划和指导治疗方法和管理方面的积极参与。技术和医学创新,如组学和分子诊断,有助于区分特定的表型/内型和正确的个体化干预措施。实施精准医学的巨大挑战将是能否以可承受的成本为每个人提供这些进展。
医学技术和创新旨在帮助全球所有患者,为需要个体化考虑的特定情况提供证据,在治疗、预测和预防疾病时让患者参与决策。我们的目标应该是随时随地都能提供精准医学。