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激活素A/骨形态发生蛋白2嵌合体（AB204）比重组人骨形态发生蛋白2具有更好的脊柱骨融合特性。

Activin A/BMP2 Chimera (AB204) Exhibits Better Spinal Bone Fusion Properties than rhBMP2.

作者信息

Ryu Dalsung, Yoon Byung-Hak, Oh Chang-Hyun, Kim Moon-Hang, Kim Ji-Yong, Yoon Seung Hwan, Choe Senyon

机构信息

Department of Neurosurgery, Inha University College of Medicine, Incheon, Korea.

Protein Engineering Laboratory, joint Center for Biosciences at Songdo Global University, Incheon, Korea.

出版信息

J Korean Neurosurg Soc. 2018 Nov;61(6):669-679. doi: 10.3340/jkns.2017.0295. Epub 2018 Oct 30.

DOI:10.3340/jkns.2017.0295
PMID:30396241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6280059/
Abstract

OBJECTIVE

To compare the spinal bone fusion properties of activin A/BMP2 chimera (AB204) with recombinant human bone morphogenetic protein (rhBMP2) using a rat posterolateral spinal fusion model.

METHODS

The study was designed to compare the effects and property at different dosages of AB204 and rhBMP2 on spinal bone fusion. Sixty-one male Sprague-Dawley rats underwent posterolateral lumbar spinal fusion using one of nine treatments during the study, that is, sham; osteon only; 3.0 μg, 6.0 μg, or 10.0 μg of rhBMP2 with osteon; and 1.0 μg, 3.0 μg, 6.0 μg, or 10.0 μg of AB204 with osteon. The effects and property on spinal bone fusion was calculated at 4 and 8 weeks after treatment using the scores of physical palpation, simple radiograph, micro-computed tomography, and immunohistochemistry.

RESULTS

Bone fusion scores were significantly higher for 10.0 μg AB204 and 10.0 μg rhBMP2 than for osteon only or 1.0 μg AB204. AB204 exhibited more prolonged osteoblastic activity than rhBMP2. Bone fusion properties of AB204 were similar with the properties of rhBMP2 at doses of 6.0 and 10.0 μg, but, the properties of AB204 at doses of 3.0 μg exhibited better than the properties of rhBMP2 at doses of 3.0 μg.

CONCLUSION

AB204 chimeras could to be more potent for treating spinal bone fusion than rhBMP2 substitutes with increased osteoblastic activity for over a longer period.

摘要

目的

使用大鼠后外侧脊柱融合模型比较激活素A/骨形态发生蛋白2嵌合体（AB204）与重组人骨形态发生蛋白（rhBMP2）的脊柱骨融合特性。

方法

本研究旨在比较不同剂量的AB204和rhBMP2对脊柱骨融合的影响和特性。61只雄性Sprague-Dawley大鼠在研究期间接受了九种治疗方法之一进行后外侧腰椎脊柱融合，即假手术；仅植入骨块；3.0μg、6.0μg或10.0μg rhBMP2与骨块联合使用；以及1.0μg、3.0μg、6.0μg或10.0μg AB204与骨块联合使用。在治疗后4周和8周，使用体格触诊、普通X线摄影、微型计算机断层扫描和免疫组织化学评分来计算对脊柱骨融合的影响和特性。

结果

10.0μg AB204和10.0μg rhBMP2的骨融合评分显著高于仅植入骨块或1.0μg AB204。AB204比rhBMP2表现出更长时间的成骨细胞活性。6.0μg和10.0μg剂量的AB204的骨融合特性与rhBMP2的特性相似，但3.0μg剂量的AB204的特性优于3.0μg剂量的rhBMP2的特性。

结论

AB204嵌合体在治疗脊柱骨融合方面可能比rhBMP2替代物更有效，具有更长时间增强的成骨细胞活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/341fc91b2042/jkns-2017-0295f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/b12b4a200d52/jkns-2017-0295f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/f406130e7ad0/jkns-2017-0295f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/2e1ff6abc23b/jkns-2017-0295f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/064d5d32e545/jkns-2017-0295f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/350e9fa0d34f/jkns-2017-0295f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/4dfeb1440f01/jkns-2017-0295f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/32aed919bd6d/jkns-2017-0295f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/341fc91b2042/jkns-2017-0295f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/b12b4a200d52/jkns-2017-0295f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/f406130e7ad0/jkns-2017-0295f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/2e1ff6abc23b/jkns-2017-0295f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/064d5d32e545/jkns-2017-0295f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/350e9fa0d34f/jkns-2017-0295f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/4dfeb1440f01/jkns-2017-0295f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/32aed919bd6d/jkns-2017-0295f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/6280059/341fc91b2042/jkns-2017-0295f8.jpg

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