a Kidney Institute and Division of Nephrology , China Medical University Hospital , Taichung , Taiwan.
b Department of Health Care Management , Chang Gung University , Taoyuan , Taiwan.
Ren Fail. 2018 Nov;40(1):514-519. doi: 10.1080/0886022X.2018.1512871.
Systemic inflammation has been reported to be associated with uremic pruritus (UP). Although a vegetarian diet can reduce systemic inflammation in hemodialysis patients, the effect of vegetarian diet on UP is not clear. The purpose of the study was to know the possible effects of vegetarian diet on UP.
A cross-sectional study was done to compare the severity of UP and blood levels of systemic inflammatory markers between vegetarian and non-vegetarian hemodialysis patients. Six non-vegetarian patients with uremic pruritus changed their non-vegetarian diet to vegetarian diet for 2 months. Visual Analogue Scale (VAS) and pruritus score (PS) were used to measure the UP severity. The serum high-sensitivity C-reactive protein (hs-CRP), and interleukin-2 (IL-2) were used as markers of inflammation.
Both the median VAS scores (p = .043) and the median PS scores (p < .001) were lower in the Vegetarian than in the non-vegetarian group. The median values of hs-CRP in Vegetarian were lower than that for the non-vegetarian (p = .020). The median value of IL-2 was also lower in Vegetarian than that of the non-vegetarian (p = .016). There were 6 non-vegetarian patients shift to vegetarian for 2 months. The pruritus score improved and IL-2 level decreased after change to vegetarian diet.
We concluded that vegetarian diet might be associated with the amelioration of the uremic pruritus severity in hemodialysis patients.
有报道称全身炎症与尿毒症瘙痒（UP）有关。虽然素食可以减少血液透析患者的全身炎症，但素食对 UP 的影响尚不清楚。本研究旨在了解素食对 UP 的可能影响。
进行了一项横断面研究，比较素食和非素食血液透析患者 UP 的严重程度和全身炎症标志物的血液水平。6 例尿毒症瘙痒的非素食患者将其非素食饮食改为素食饮食 2 个月。使用视觉模拟量表（VAS）和瘙痒评分（PS）来衡量 UP 的严重程度。血清高敏 C 反应蛋白（hs-CRP）和白细胞介素 2（IL-2）被用作炎症标志物。
素食组的中位数 VAS 评分（p=0.043）和中位数 PS 评分（p<0.001）均低于非素食组。素食组的 hs-CRP 中位数低于非素食组（p=0.020）。素食组的 IL-2 中位数也低于非素食组（p=0.016）。有 6 名非素食患者改为素食 2 个月。改为素食饮食后，瘙痒评分改善，IL-2 水平下降。
我们的结论是，素食可能与血液透析患者尿毒症瘙痒严重程度的改善有关。
