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用于生物医学应用的低成本β钛锰合金的微观结构、力学性能和细胞毒性

Microstructures, mechanical properties and cytotoxicity of low cost beta Ti-Mn alloys for biomedical applications.

作者信息

Santos Pedro Fernandes, Niinomi Mitsuo, Cho Ken, Nakai Masaaki, Liu Huihong, Ohtsu Naofumi, Hirano Mitsuhiro, Ikeda Masahiko, Narushima Takayuki

机构信息

Department of Metallurgy, Materials Science and Materials Processing, Tohoku University, 6-6 Aoba, Aramaki, Aoba-Ku, Sendai, Miyagi 980-8579, Japan.

Tohoku University, Aoba-ku, Katahira 2-1-1, Institute for Materials Research, Building 2, Sendai, Miyagi 980-8577, Japan.

出版信息

Acta Biomater. 2015 Oct;26:366-76. doi: 10.1016/j.actbio.2015.08.015. Epub 2015 Aug 14.

Abstract

UNLABELLED

The microstructures, mechanical properties and biocompatibility of low cost β-type Ti-(6-18)Mn alloys were investigated after solution treatment. Ti-9 Mn exhibits the best combination of tensile strength and elongation among the fabricated alloys, and its performance is comparable to or superior to those of Ti-6Al-4V ELI (Ti-64 ELI) in terms of every parameter evaluated. A hardness of 338 HV, a Young's modulus of 94 GPa, a 0.2% proof stress of 1023 MPa, an ultimate tensile strength of 1048 MPa and elongation of 19% were obtained for Ti-9 Mn. Furthermore, the cell viability and metallic ion release ratios are comparable to those of commercially pure titanium, making this alloy promising for biomedical applications. The Young's modulus is also lower than that of Ti-64 ELI (110 GPa), which can possibly reduce the stress shielding effect in implanted patients.

STATEMENT OF SIGNIFICANCE

This study evaluates mechanical and biological performance of low cost solution treated β-type Ti-(6, 9, 13 and 18 mass%)Mn alloys. It includes alloys containing a Mn content range higher than most previously published works (which is around or lower than 8 mass%). Furthermore, the effects of the ω phase and the β phase stability of the alloys over some mechanical properties and microstructures are discussed. Ion release behavior under simulated body fluids and cell viability are also evaluated. For the case of the Ti-9 Mn, a mechanical and biological performance that is comparable to or superior than that of the widely used Ti-6Al-4V ELI and commercially pure Ti was observed.

摘要

未标注

对低成本β型Ti-(6 - 18)Mn合金固溶处理后的微观结构、力学性能和生物相容性进行了研究。Ti-9 Mn在制备的合金中展现出最佳的拉伸强度和伸长率组合,并且在评估的各项参数方面,其性能与Ti-6Al-4V ELI(Ti-64 ELI)相当或更优。Ti-9 Mn的硬度为338 HV,杨氏模量为94 GPa,0.2% 屈服强度为1023 MPa,极限抗拉强度为1048 MPa,伸长率为19%。此外,细胞活力和金属离子释放率与商业纯钛相当,这使得该合金在生物医学应用方面具有前景。其杨氏模量也低于Ti-64 ELI(110 GPa),这可能会降低植入患者体内的应力屏蔽效应。

重要性声明

本研究评估了低成本固溶处理的β型Ti-(6、9、13和18质量%)Mn合金的力学和生物学性能。研究包括了锰含量范围高于大多数先前发表作品(大多在或低于8质量%左右)的合金。此外,还讨论了合金的ω相和β相稳定性对一些力学性能和微观结构的影响。还评估了模拟体液下的离子释放行为和细胞活力。对于Ti-9 Mn而言,观察到其力学和生物学性能与广泛使用的Ti-6Al-

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