Christensson B, Braconier J H, Winqvist I, Relander T, Dictor M
Scand J Infect Dis. 1987;19(3):373-9. doi: 10.3109/00365548709018485.
A fatal case of infectious mononucleosis due to serologically verified Epstein-Barr virus infection in a previously healthy 30-year-old man is presented. The clinical course was characterized by severe prostration, persistently high spiking fever, and continuous development of enlarged lymph nodes. Hematologic examination revealed peripheral leukopenia and thrombocytopenia, and in the bone marrow an increased number of benign histiocytes showed marked hemophagocytosis. At autopsy abnormal lymphoid infiltrates were present in several tissues. The pathogenesis of this infection-associated hemophagocytic syndrome is discussed in terms of the possibility of an impaired immune response to infectious agents.
本文报告了一例经血清学证实为EB病毒感染的传染性单核细胞增多症致死病例，患者为一名30岁此前健康的男性。临床病程的特点是严重衰弱、持续高热、淋巴结持续肿大。血液学检查显示外周血白细胞减少和血小板减少，骨髓中良性组织细胞数量增加并表现出明显的噬血细胞现象。尸检发现多个组织中有异常的淋巴浸润。本文从对感染因子免疫反应受损的可能性方面讨论了这种感染相关噬血细胞综合征的发病机制。
