Okano M, Gross T G
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Am J Hematol. 1996 Oct;53(2):111-5. doi: 10.1002/(SICI)1096-8652(199610)53:2<111::AID-AJH8>3.0.CO;2-2.
Virus-associated hemophagocytic syndrome (VAHS) has been thought to be a distinct clinical entity, characterized by intermittent fever, enlarged liver and spleen, and the appearance of hemophagocytosis. Hemopoietic cells are actively ingested by monocytes/macrophages in various organs, including lymph nodes, bone marrow, liver, and spleen. Epstein-Barr virus (EBV) is now thought to be one of the major causes for the development of this unique syndrome. Additionally, VAHS is often associated with fatal infectious mononucleosis (IM). The relationship between EBV-associated VAHS and fatal IM is discussed in this concise review.
病毒相关性噬血细胞综合征（VAHS）被认为是一种独特的临床实体，其特征为间歇性发热、肝脾肿大以及噬血细胞现象的出现。造血细胞在包括淋巴结、骨髓、肝脏和脾脏在内的各个器官中被单核细胞/巨噬细胞主动吞噬。现在认为，爱泼斯坦-巴尔病毒（EBV）是导致这种独特综合征发生的主要原因之一。此外，VAHS常与致命性传染性单核细胞增多症（IM）相关。本简要综述讨论了EBV相关的VAHS与致命性IM之间的关系。
