• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甲状腺恶性肿瘤中胱硫醚β-合酶水平升高。

Cystathione β-Synthase Is Increased in Thyroid Malignancies.

作者信息

Turbat-Herrera Elba A, Kilpatrick Matthew J, Chen Jie, Meram Andrew T, Cotelingam James, Ghali Ghali, Kevil Christopher G, Coppola Domenico, Shackelford Rodney E

机构信息

Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.

Head & Neck Oncologic/Microvascular Reconstructive Surgery Department of Oral & Maxillofacial/Head & Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.

出版信息

Anticancer Res. 2018 Nov;38(11):6085-6090. doi: 10.21873/anticanres.12958.

DOI:10.21873/anticanres.12958
PMID:30396922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7771238/
Abstract

BACKGROUND

Cystathione β-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (HS) and cystathione, via the trans-sulfuration pathway. CBS protein expression levels are increased in several different human malignancies, with increased protein expression correlating with parameters such as tumor stage, anaplasia, metastases, and chemotherapy resistance.

MATERIALS AND METHODS

This study employed tissue microarrays to examine CBS expression in benign thyroid tissue, thyroid oncocytomas, thyroid follicular adenomas, and in follicular, papillary, anaplastic, and medullary thyroid carcinomas.

RESULTS

CBS expression was increased in all thyroid carcinomas types compared to benign thyroid tissue, but not in thyroid follicular adenomas or oncocytomas. A similar pattern was observed for nicotinamide phosphoribosyltransferase (NAMPT) tissue microarray analysis comparing thyroid adenomas and follicular carcinomas.

CONCLUSION

For the first time, we showed that an HS-syntheszing enzyme plays a role in thyroid malignancies. Additionally, our data suggest that CBS and NAMPT immunohistochemistry may be useful in differentiating follicular adenomas from follicular carcinomas.

摘要

背景

胱硫醚β-合酶（CBS）通过转硫途径催化同型半胱氨酸和半胱氨酸转化为硫化氢（HS）和胱硫醚。在几种不同的人类恶性肿瘤中，CBS蛋白表达水平升高，蛋白表达增加与肿瘤分期、间变、转移和化疗耐药性等参数相关。

材料与方法

本研究采用组织芯片检测CBS在良性甲状腺组织、甲状腺嗜酸细胞瘤、甲状腺滤泡性腺瘤以及滤泡状、乳头状、间变性和髓样甲状腺癌中的表达。

结果

与良性甲状腺组织相比，所有类型的甲状腺癌中CBS表达均增加，但在甲状腺滤泡性腺瘤或嗜酸细胞瘤中未增加。在比较甲状腺腺瘤和滤泡状癌的烟酰胺磷酸核糖转移酶（NAMPT）组织芯片分析中也观察到类似模式。

结论

我们首次表明一种HS合成酶在甲状腺恶性肿瘤中起作用。此外，我们的数据表明CBS和NAMPT免疫组织化学可能有助于鉴别滤泡性腺瘤和滤泡状癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/7771238/19a17c4f455b/nihms-1655790-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/7771238/6acf44ec5a53/nihms-1655790-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/7771238/19a17c4f455b/nihms-1655790-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/7771238/6acf44ec5a53/nihms-1655790-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5555/7771238/19a17c4f455b/nihms-1655790-f0002.jpg

相似文献

1
Cystathione β-Synthase Is Increased in Thyroid Malignancies.甲状腺恶性肿瘤中胱硫醚β-合酶水平升高。
Anticancer Res. 2018 Nov;38(11):6085-6090. doi: 10.21873/anticanres.12958.
2
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.肾嗜酸细胞瘤、肾尿路上皮癌和肾透明细胞癌中烟酰胺磷酸核糖转移酶和胱硫醚-β-合酶增加。
Anticancer Res. 2017 Jul;37(7):3423-3427. doi: 10.21873/anticanres.11709.
3
Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas.烟酰胺磷酸核糖基转移酶和 SIRT3 的表达在分化良好的甲状腺癌中增加。
Anticancer Res. 2013 Aug;33(8):3047-52.
4
Expression of inducible nitric oxide synthase in thyroid neoplasms: immunohistochemical and molecular analysis.诱导型一氧化氮合酶在甲状腺肿瘤中的表达：免疫组织化学和分子分析。
Pathol Int. 2003 Jul;53(7):434-9. doi: 10.1046/j.1440-1827.2003.01501.x.
5
NITRIC OXIDE SYNTHASE ACTIVITY AND ITS CONCENTRATION IN THE TISSUES OF HUMAN THYROID CARCINOMAS.人甲状腺癌组织中一氧化氮合酶活性及其浓度
Fiziol Zh (1994). 2016;62(3):9-19. doi: 10.15407/fz62.03.009.
6
The natural protein kinase C alpha mutant is present in human thyroid neoplasms.天然蛋白激酶Cα突变体存在于人类甲状腺肿瘤中。
Oncogene. 1995 Aug 17;11(4):669-74.
7
E-cadherin/α-catenin deregulated co-expression in thyroid carcinoma based on tissue microarray digital image analysis.基于组织芯片数字图像分析的甲状腺癌中E-钙黏蛋白/α-连环蛋白失调共表达
J BUON. 2016 Mar-Apr;21(2):450-5.
8
Dipeptidyl aminopeptidase IV in the cytologic diagnosis of thyroid carcinoma.二肽基肽酶IV在甲状腺癌的细胞学诊断中的应用
Diagn Cytopathol. 1998 Jul 1;19(1):4-8. doi: 10.1002/(sici)1097-0339(199807)19:1<4::aid-dc2>3.0.co;2-g.
9
CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study.基于高通量组织芯片研究，CITED1蛋白表达提示甲状腺乳头状癌。
Thyroid. 2004 Mar;14(3):169-75. doi: 10.1089/105072504773297830.
10
[Cytokeratin expression of benign and malignant epithelial thyroid gland tumors. An immunohistologic study of 154 neoplasms using 8 different monoclonal cytokeratin antibodies].[甲状腺良恶性上皮性肿瘤的细胞角蛋白表达。应用8种不同单克隆细胞角蛋白抗体对154例肿瘤进行的免疫组织学研究]
Pathologe. 1996 Nov;17(6):425-32. doi: 10.1007/s002920050181.

引用本文的文献

1
Human Menstrual Blood-Derived Stem Cells Protect against Tacrolimus-Induced Islet Dysfunction via Cystathionine β-Synthase Mediated IL-6/STAT3 Inactivation.人月经血来源的干细胞通过胱硫醚β-合酶介导的 IL-6/STAT3 失活来防止他克莫司诱导的胰岛功能障碍。
Biomolecules. 2024 Jun 8;14(6):671. doi: 10.3390/biom14060671.
2
Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review.硫化氢在肿瘤性和非肿瘤性疾病中的作用及其受非编码RNA的调控：综述
Noncoding RNA. 2024 Jan 18;10(1):7. doi: 10.3390/ncrna10010007.
3
Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment.

本文引用的文献

1
Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae.与相邻的良性口腔黏膜相比，口腔鳞状细胞癌中硫化氢水平升高。
Anticancer Res. 2018 Jul;38(7):3843-3852. doi: 10.21873/anticanres.12668.
2
Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia.烟酰胺磷酸核糖转移酶：宫颈发育异常进展的可靠标志物
Anticancer Res. 2017 Sep;37(9):4821-4825. doi: 10.21873/anticanres.11889.
3
Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.
将同型半胱氨酸和硫化氢平衡作为癌症治疗的未来疗法
Antioxidants (Basel). 2023 Jul 29;12(8):1520. doi: 10.3390/antiox12081520.
4
Cystathionine β-synthase affects organization of cytoskeleton and modulates carcinogenesis in colorectal carcinoma cells.胱硫醚β-合酶影响细胞骨架的组织并调节结肠癌细胞的致癌作用。
Front Oncol. 2023 Jul 7;13:1178021. doi: 10.3389/fonc.2023.1178021. eCollection 2023.
5
Recent advances in the role of endogenous hydrogen sulphide in cancer cells.内源性硫化氢在癌细胞中的作用的最新进展。
Cell Prolif. 2023 Sep;56(9):e13449. doi: 10.1111/cpr.13449. Epub 2023 Mar 16.
6
Cystathionine -Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.胱硫醚-β-合酶调控甲状腺癌细胞的增殖、迁移和侵袭。
Oxid Med Cell Longev. 2022 Jun 27;2022:8678363. doi: 10.1155/2022/8678363. eCollection 2022.
7
Hydrogen Sulfide Suppresses Skin Fibroblast Proliferation Oxidative Stress Alleviation and Necroptosis Inhibition.硫化氢抑制皮肤成纤维细胞增殖、减轻氧化应激并抑制坏死性凋亡。
Oxid Med Cell Longev. 2022 Jun 21;2022:7434733. doi: 10.1155/2022/7434733. eCollection 2022.
8
Emerging roles of cystathionine β-synthase in various forms of cancer.胱硫醚β-合酶在各种形式癌症中的新兴作用。
Redox Biol. 2022 Jul;53:102331. doi: 10.1016/j.redox.2022.102331. Epub 2022 May 10.
9
Molecular Functions of Hydrogen Sulfide in Cancer.硫化氢在癌症中的分子功能
Pathophysiology. 2021 Sep 20;28(3):437-456. doi: 10.3390/pathophysiology28030028.
10
Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1.硫化氢通过上调沉默调节蛋白-1促进甲状腺激素的合成与分泌。
Front Pharmacol. 2022 Feb 10;13:838248. doi: 10.3389/fphar.2022.838248. eCollection 2022.
肾嗜酸细胞瘤、肾尿路上皮癌和肾透明细胞癌中烟酰胺磷酸核糖转移酶和胱硫醚-β-合酶增加。
Anticancer Res. 2017 Jul;37(7):3423-3427. doi: 10.21873/anticanres.11709.
4
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma.甲状腺滤泡性腺瘤的突变负荷和进化年龄与滤泡性癌相当。
Oncotarget. 2016 Oct 25;7(43):69638-69648. doi: 10.18632/oncotarget.11922.
5
Increased Nicotinamide Phosphoribosyltransferase in Rhabdomyosarcomas and Leiomyosarcomas Compared to Skeletal and Smooth Muscle Tissue.与骨骼肌和平滑肌组织相比，横纹肌肉瘤和平滑肌肉瘤中烟酰胺磷酸核糖转移酶增加。
Anticancer Res. 2016 Feb;36(2):503-7.
6
Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladder.硫化氢及其合成酶的表达谱与膀胱尿路上皮细胞癌的肿瘤分期和分级相关。
Urol Oncol. 2016 Apr;34(4):166.e15-20. doi: 10.1016/j.urolonc.2015.06.020. Epub 2016 Feb 1.
7
Role of cystathionine β-synthase in human breast Cancer.半胱氨酸β-合酶在人乳腺癌中的作用。
Free Radic Biol Med. 2015 Sep;86:228-38. doi: 10.1016/j.freeradbiomed.2015.05.024. Epub 2015 Jun 4.
8
Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression.烟酰胺磷酸核糖基转移酶在甲状腺恶性肿瘤中的过表达及其与肿瘤分期和生存素/生存素DEx3表达的相关性。
Tumour Biol. 2015 Sep;36(10):7859-63. doi: 10.1007/s13277-015-3506-z. Epub 2015 May 7.
9
A H2S-Nampt dependent energetic circuit is critical to survival and cytoprotection from damage in cancer cells.一种依赖于硫化氢（H2S）和烟酰胺磷酸核糖转移酶（Nampt）的能量代谢途径对于癌细胞的存活及免受损伤的细胞保护作用至关重要。
PLoS One. 2014 Sep 23;9(9):e108537. doi: 10.1371/journal.pone.0108537. eCollection 2014.
10
Nicotinamide phosphoribosyltransferase in malignancy: a review.恶性肿瘤中的烟酰胺磷酸核糖转移酶：综述
Genes Cancer. 2013 Nov;4(11-12):447-56. doi: 10.1177/1947601913507576.