Kitazawa M, Ohnishi Y, Nonomura N, Kobayashi E
Acta Pathol Jpn. 1987 Mar;37(3):515-26. doi: 10.1111/j.1440-1827.1987.tb00386.x.
A case of undifferentiated carcinoma arising from benign lymphoepithelial lesion (BLEL) of the parotid gland was studied by light and electron microscopy. Histopathologically, the carcinoma was composed of pleomorphic anaplastic cells showing an undifferentiated type among abundant lymphoid tissue forming germinal center. Among the prominent lymphoid tissue, epithelial hyperplasia, dysplasia, and squamous metaplasia of the duct epithelium were found. Dysplastic epithelium revealed a transition with carcinomatous component in some areas. On the electron microscopic observation, the tumor cells were poorly differentiated, possessing desmosomes and intracytoplasmic filaments. The patient is alive and well 2 months after resection of the tumor, but has a high titer of serum Epstein-Barr virus capsid antigen in IgG. Eighty five cases of the malignant lymphoepithelial lesion (MLEL) including the present case are summarized.
通过光镜和电镜对1例起源于腮腺良性淋巴上皮病变（BLEL）的未分化癌进行了研究。组织病理学上，癌由多形性间变细胞组成，在形成生发中心的丰富淋巴组织中呈未分化型。在显著的淋巴组织中，发现导管上皮有上皮增生、发育异常和鳞状化生。发育异常的上皮在某些区域显示出与癌成分的移行。电镜观察显示，肿瘤细胞分化差，具有桥粒和胞质内细丝。该患者在肿瘤切除术后2个月情况良好，但血清中IgG型Epstein-Barr病毒衣壳抗原滴度较高。总结了包括本病例在内的85例恶性淋巴上皮病变（MLEL）。
