Nagao K, Matsuzaki O, Saiga H, Akikusa B, Sugano I, Shigematsu H, Kaneko T, Katoh T, Kitamura T, Asano Y, Okamoto M
Cancer. 1983 Sep 15;52(6):1044-52. doi: 10.1002/1097-0142(19830915)52:6<1044::aid-cncr2820520620>3.0.co;2-r.
Twenty-three cases of benign and malignant lymphoepithelial lesions without Sjögren's syndrome were examined: 21 were classical benign lymphoepithelial lesions, and were mostly found in males older than 50 years of age. The other two cases were identified as undifferentiated carcinoma arising from benign lymphoepithelial lesion (8.7%; 2/23). Histologically, this carcinoma is characterized by the formation of cell nests of variable size and by marked lymphoplasmacytic infiltrations into the stromal tissue. In immunofluorescence, an increase of plasma cells containing IgA and IgG was noted in the marginal areas of carcinoma cell clusters. Electron microscopy disclosed that the carcinoma was composed of poorly differentiated cells with occasional squamous differentiation. No dysplastic characteristics were found in the infiltrating lymphocytic components. These two cases of carcinoma were found in middle-aged females.
对23例无干燥综合征的良性和恶性淋巴上皮病变进行了检查：21例为典型的良性淋巴上皮病变，多见于50岁以上男性。另外2例被诊断为起源于良性淋巴上皮病变的未分化癌（8.7%；2/23）。组织学上，这种癌的特征是形成大小不一的细胞巢，并伴有明显的淋巴浆细胞浸润到间质组织中。免疫荧光检查发现，癌细胞簇边缘区域含IgA和IgG的浆细胞增多。电子显微镜检查显示，该癌由分化不良的细胞组成，偶见鳞状分化。浸润的淋巴细胞成分未发现发育异常特征。这2例癌均见于中年女性。
