Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Eur J Cancer Prev. 2019 Nov;28(6):544-550. doi: 10.1097/CEJ.0000000000000489.
There is a great need for efficient and cost-effective melanoma screening, but this is not yet solved. Epidemiological studies on trends in melanoma incidence by tumour thickness, anatomical site and demographical data can help to improve public health efforts regarding earlier melanoma diagnosis. We aimed to study the trends in the incidence and characteristics of patients and their melanoma in North-East Hungary from 2000 to 2014. Data were obtained from a university hospital-based registry. A total of 1509 cutaneous invasive melanomas of 1464 patients were included in the study. A moderate but significant increase in incidence was observed in the region [average annual percentage change: 3.04 (0.07; 6.11); P = 0.045], with a breakpoint in 2007. From 2001 to 2007, the trend was increasing [APC: 9.84 (3.52; 16.55); P=0.006], but it stalled from 2007 [APC: -2.45 (-5.99; 1.23); P = 0.164]. However, in the age groups over the age of 60 years, where the standardised incidence was the highest, the incidence continued to rise. Furthermore, older age, male sex and trunk or lower extremity localization were found to be associated with thicker melanomas. Our results support that regular screening examination for melanoma would be desirable for people over the age of 60 years.
目前非常需要高效且具有成本效益的黑色素瘤筛查方法，但这一需求仍未得到满足。通过肿瘤厚度、解剖部位和人口统计学数据对黑色素瘤发病率趋势进行的流行病学研究，有助于改善与早期黑色素瘤诊断相关的公共卫生工作。我们旨在研究 2000 年至 2014 年期间，匈牙利东北部黑色素瘤发病率和患者及其黑色素瘤特征的变化趋势。研究数据来自一家大学医院的登记处。共纳入了 1464 名患者的 1509 例侵袭性皮肤黑色素瘤。该地区的发病率呈中度但显著上升[平均年变化百分比：3.04（0.07；6.11）；P=0.045]，2007 年出现拐点。2001 年至 2007 年，发病率呈上升趋势[APC：9.84（3.52；16.55）；P=0.006]，但自 2007 年以来趋于平稳[APC：-2.45（-5.99；1.23）；P=0.164]。然而，在标准发病率最高的 60 岁以上年龄组中，发病率仍在继续上升。此外，年龄较大、男性和躯干或下肢定位与黑色素瘤厚度增加有关。我们的研究结果表明，对于 60 岁以上的人群，定期进行黑色素瘤筛查是可取的。
