间充质干细胞旁分泌作用作为糖尿病肾病的一种新的治疗策略。
Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy.
机构信息
Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
出版信息
Life Sci. 2018 Dec 15;215:113-118. doi: 10.1016/j.lfs.2018.11.001. Epub 2018 Nov 3.
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease.
糖尿病肾病（DN）是糖尿病（DM）的一种微血管并发症，也是终末期肾脏疾病（ESRD）的主要原因。基于间充质干细胞（MSCs）在再生医学中的作用，MSC 治疗被认为是改善 DN 进展的一种很有前途的策略。本文主要综述了 MSC 旁分泌机制（基于营养因子和细胞外囊泡）在 DN 中的治疗潜力。了解 MSC 对 DN 的治疗作用的机制可以为这种疾病提供急需的新药物靶点。
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