Hu Wei-Ting, Li Ming, Ma Pei-Jun, Yang Ding, Liu Xiao-Dong, Wang Yun
Department of Clinical Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China.
Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Arch Toxicol. 2025 Apr 1. doi: 10.1007/s00204-025-04036-w.
Chemokine CCL5 (RANTES), as a key mediator of intercellular communication in cancers, and its role in cancer development, metastasis and immune escape has received increasing attention. CCL5 and its receptors are important components of the tumor microenvironment and play a tumor promoting role in different ways by triggering signaling pathways through binding to the primary receptor CCR5. CCL5 was viewed as indispensable "gate keepers" of immunity and inflammation, it remains unclear of CCL5-mediated intercellular communication. Therefore, in this review, we summarize the latest information on the origin, structure, and characterization of CCL5 and role of CCL5 in the tumor microenvironment. It includes CCL5-mediated intercellular communication through exosomes, microvesicles and others in breast, lung, and ovarian cancers. CCL5 has a multifaceted role in cancer and has potential applications as a biomarker for cancer diagnosis and prognosis, which provides theoretical bases and therapeutic targets for the development of new cancer therapeutic strategies.
趋化因子CCL5（调节激活正常T细胞表达和分泌的因子）作为癌症中细胞间通讯的关键介质，其在癌症发生、转移和免疫逃逸中的作用受到越来越多的关注。CCL5及其受体是肿瘤微环境的重要组成部分，通过与主要受体CCR5结合触发信号通路，以不同方式发挥促肿瘤作用。CCL5被视为免疫和炎症不可或缺的“守门人”，CCL5介导的细胞间通讯仍不清楚。因此，在本综述中，我们总结了关于CCL5的起源、结构、特征以及CCL5在肿瘤微环境中的作用的最新信息。它包括CCL5通过外泌体、微囊泡等在乳腺癌、肺癌和卵巢癌中介导的细胞间通讯。CCL5在癌症中具有多方面作用，并且作为癌症诊断和预后的生物标志物具有潜在应用价值，这为开发新的癌症治疗策略提供了理论依据和治疗靶点。
