Uehara A, Gottschall P E, Dahl R R, Arimura A
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1286-90. doi: 10.1016/0006-291x(87)90788-1.
Ever since two distinct molecules of human interleukin-1 (termed interleukin-1 alpha and interleukin-1 beta) were cloned, sequenced and expressed, it has been a matter of investigation whether these two forms of interleukin-1 possess an identical spectrum of biological activities. Our current studies of interleukin-1 and its involvement in the hypothalamic-pituitary-adrenal axis have indicated that there is a clear-cut differential response to interleukin-1 alpha and interleukin-1 beta. The intravenous injection of human recombinant interleukin-1 beta significantly increased the plasma levels of adrenocorticotropic hormone in a dose-related manner, whereas interleukin-1 alpha did not. This observation suggests for the first time that the two members of the interleukin-1 family may have a different spectrum of biological actions.
自从人类白细胞介素-1的两种不同分子（称为白细胞介素-1α和白细胞介素-1β）被克隆、测序和表达以来，这两种形式的白细胞介素-1是否具有相同的生物活性谱一直是一个研究课题。我们目前对白细胞介素-1及其参与下丘脑-垂体-肾上腺轴的研究表明，对白细胞介素-1α和白细胞介素-1β存在明显的差异反应。静脉注射重组人白细胞介素-1β以剂量相关的方式显著提高了促肾上腺皮质激素的血浆水平，而白细胞介素-1α则没有。这一观察结果首次表明白细胞介素-1家族的两个成员可能具有不同的生物作用谱。
