Naitoh Y, Fukata J, Tominaga T, Nakai Y, Tamai S, Mori K, Imura H
Department of Anesthesiology, Kyoto University Faculty of Medicine, Japan.
Biochem Biophys Res Commun. 1988 Sep 30;155(3):1459-63. doi: 10.1016/s0006-291x(88)81305-6.
In order to assess the effect of interleukin-6 on the hypothalamo-pituitary-adrenal axis, we administered recombinant human interleukin-6 to conscious, freely-moving rats. The intravenous injection of interleukin-6 significantly increased the plasma level of adrenocorticotropic hormone 30 min after the injection in a dose-related manner. Immunoneutralization of corticotropin-releasing hormone blocked the stimulatory effects of interleukin-6 on adrenocorticotropic hormone secretion. These observations suggest that interleukin-6 stimulates the secretion of adrenocorticotropic hormone through the corticotropin-releasing hormone and is possibly involved in the interaction between the neuroendocrine and immune system.
为了评估白细胞介素-6对下丘脑-垂体-肾上腺轴的作用，我们对清醒、自由活动的大鼠注射重组人白细胞介素-6。静脉注射白细胞介素-6后30分钟，促肾上腺皮质激素的血浆水平以剂量相关的方式显著升高。促肾上腺皮质激素释放激素的免疫中和作用阻断了白细胞介素-6对促肾上腺皮质激素分泌的刺激作用。这些观察结果表明，白细胞介素-6通过促肾上腺皮质激素释放激素刺激促肾上腺皮质激素的分泌，并且可能参与神经内分泌和免疫系统之间的相互作用。
