School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea.
Forest Resources Development Institute of Gyeongsangbuk-do, Andong 36605, Korea.
Nutrients. 2018 Nov 5;10(11):1680. doi: 10.3390/nu10111680.
Gastric ulcer is a major digestive disorder and provoked by multifactorial etiologies, including excessive alcohol consumption. In this study, we examined the gastroprotective effect of aqueous and ethanolic extracts of Decne (DBD; commonly called Chinese yam) flesh or peel against acidified ethanol-induced acute gastric damage in mice. Our findings demonstrated that oral supplementation of aqueous or ethanolic extracts of DBD flesh or peel before ulcer induction was significantly effective in macroscopically and histologically alleviating ethanol-induced pathological lesions in gastric mucosa, decreasing the plasma levels of inflammatory mediators, such as nitric oxide and interleukin-6, attenuating the gastric expression of cyclooxygenase-2, and increasing the gastric content of prostaglandin E₂. In particular, pretreatment with the flesh extract prepared in 60% ethanol prominently decreased the expression of biomarkers of oxidative stress, including the plasma levels of 8-hydroxy-2-guanosine and malondialdehyde, and restored heme oxygenase-1 expression and superoxide dismutase activity in the stomach. Overall, these findings suggest that the oral supplementation with DBD extract, especially flesh ethanol extract, prior to excessive alcohol consumption, may exert a protective effect against ethanol-induced gastric mucosal damage in vivo, presumably through the activation of the antioxidant system and suppression of the inflammatory response.
胃溃疡是一种主要的消化系统疾病，由多种病因引起，包括过度饮酒。在这项研究中，我们研究了山药(DBD)的水提物和醇提物对酸化乙醇诱导的小鼠急性胃损伤的胃保护作用。我们的研究结果表明，在溃疡诱导前口服补充 DBD 的水提物或醇提物对胃黏膜的乙醇诱导病理损伤具有明显的缓解作用，能降低血浆中一氧化氮和白细胞介素-6 等炎症介质的水平，减弱胃环氧化酶-2 的表达，并增加胃内前列腺素 E₂的含量。特别是，用 60%乙醇制备的山药肉提取物预处理能显著降低氧化应激生物标志物的表达，包括血浆中 8-羟基-2-鸟苷和丙二醛的水平，并恢复胃中血红素加氧酶-1 的表达和超氧化物歧化酶的活性。总的来说，这些发现表明，在过量饮酒前口服补充 DBD 提取物，特别是山药肉醇提物，可能会在体内发挥对抗乙醇诱导的胃黏膜损伤的保护作用，这可能是通过激活抗氧化系统和抑制炎症反应来实现的。
