Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Molecules. 2020 Nov 29;25(23):5623. doi: 10.3390/molecules25235623.
Inulae Flos, the flower of L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E (PGE) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers.
款冬花，是一种原产于亚洲东部的植物，被用作膳食补充剂、饮料和药物。在本研究中，我们评估了款冬花提取物（IFE）对盐酸/乙醇诱导的大鼠胃黏膜损伤的胃保护作用，并通过测量抗氧化酶活性、黏液分泌和前列腺素 E（PGE）水平来探讨其潜在机制。IFE 在 100 和 300mg/kg 剂量下预处理可显著抑制盐酸/乙醇处理大鼠的胃损伤。IFE 增加了超氧化物歧化酶和过氧化氢酶的活性以及胃组织中谷胱甘肽和 PGE 的水平。IFE 的给药还显著增加了盐酸/乙醇诱导的胃损伤中胃壁黏液的含量。这些发现表明，IFE 对盐酸/乙醇诱导的胃损伤具有胃保护作用，其通过增加抗氧化水平和胃黏液分泌来发挥作用。款冬花可能是预防和治疗胃炎和胃溃疡的有前途的药物。
