Gut Liver. 2019 May 15;13(3):308-314. doi: 10.5009/gnl18175.
Whether moderate alcohol intake is beneficial remains an unsolved issue. Recent studies have suggested that moderate alcohol consumption is associated with beneficial effects related to the prevention of cardiovascular diseases. Moderate alcohol consumption leads to a higher risk of hepatocellular carcinoma in patients with chronic viral liver diseases. However, the effects of moderate alcohol intake in patients with nonalcoholic fatty liver disease are unclear. In this review, we analyzed, from various perspectives, the effect of moderate alcohol consumption in patients with nonalcoholic fatty liver disease. We reviewed four cohort studies and seven cross-sectional studies. The results showed that moderate alcohol consumption was negatively related to the incidence of nonalcoholic steatohepatitis and liver fibrosis. However, moderate alcohol consumption was positively associated with the incidence of hepatocellular carcinoma in patients with nonalcoholic fatty liver disease. The results of the analysis of the relationship between moderate alcohol consumption and the levels of triglycerides, total cholesterol, high-density lipoprotein, and hypertension were diverse. More clinical data are needed to draw a conclusion about the effects of moderate alcohol consumption in patients with nonalcoholic fatty liver disease.
适量饮酒是否有益仍然是一个悬而未决的问题。最近的研究表明，适量饮酒与预防心血管疾病的有益作用有关。适量饮酒会增加慢性病毒性肝病患者肝细胞癌的风险。然而，非酒精性脂肪性肝病患者适量饮酒的影响尚不清楚。在这篇综述中，我们从多个角度分析了非酒精性脂肪性肝病患者适量饮酒的效果。我们回顾了四项队列研究和七项横断面研究。结果表明，适量饮酒与非酒精性脂肪性肝炎和肝纤维化的发生率呈负相关。然而，适量饮酒与非酒精性脂肪性肝病患者肝细胞癌的发生率呈正相关。分析适量饮酒与甘油三酯、总胆固醇、高密度脂蛋白和高血压水平之间关系的结果各不相同。需要更多的临床数据来得出关于非酒精性脂肪性肝病患者适量饮酒影响的结论。
