Sakamoto Jinichi, Kamiura Shoji, Okayama Kaori, Okodo Mitsuaki, Shibata Takeo, Osaka Yasuhiro, Fujita Satoko, Takata Emi, Takagi Hiroaki, Takakura Masahiro, Sasagawa Toshiyuki
Kanazawa Medical University, Daigaku 1-1, Uchinada-cho, Kahoku-gun, Ishikawa 920-0265, Japan.
Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka-shi, 541-8567 Osaka, Japan.
Papillomavirus Res. 2018 Dec;6:46-51. doi: 10.1016/j.pvr.2018.10.001. Epub 2018 Oct 26.
To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed in 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cervical cancer (ICC) patients with the novel Genosearch-31+5 HPV test. The HPV-positive rates were 89.3% and 90.8% in CIN and ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) types excluding HPV 35, and probably HR HPV 53, 67, 69, and 70 were identified in ICC, suggesting that all these types may be oncogenic. HPV16 and 18 were identified in both SCC and adenocarcinoma (ADC). HPV HPV52, 31 and 58 (alpha-9) were predominantly detected in SCC, whereas HPV 18, 45, 39 and 59 (alpha-7) were in ADC. The prevalence of HPV 18 in SCC significantly decreased with increasing age of patients, whereas the opposite trend was observed in the other HR types. HPV18 is likely to induce SCC rapidly. All ICC cases aged 20-29 were positive for HPV 16 or 18, suggesting that present HPV 16, 18 vaccines may be quite effective to prevent ICC in young women.
为阐明日本致癌性人乳头瘤病毒（HPV）的类型，采用新型Genosearch-31+5 HPV检测方法对1526例宫颈上皮内瘤变（CIN）患者和371例浸润性宫颈癌（ICC）患者进行了HPV基因分型。CIN和ICC患者的HPV阳性率分别为89.3%和90.8%。关于单一型感染，在ICC中鉴定出13种国际公认的高危（13HR）型（不包括HPV 35）以及可能的HR型HPV 53、67、69和70，这表明所有这些类型可能都具有致癌性。在鳞状细胞癌（SCC）和腺癌（ADC）中均鉴定出HPV16和18。HPV 52、31和58（α-9）主要在SCC中检测到，而HPV 18、45、39和59（α-7）则在ADC中检测到。SCC中HPV 18的患病率随患者年龄增加而显著降低，而其他HR型则呈现相反趋势。HPV18可能会迅速诱发SCC。所有年龄在20至29岁的ICC病例HPV 16或18均呈阳性，这表明目前的HPV 16、18疫苗可能对预防年轻女性的ICC非常有效。
