College of Nursing, Yonsei University, Seoul, 03722, South Korea.
Mo-Im Kim Nursing Research Institute, Seoul, 03722, South Korea.
Sci Rep. 2018 Nov 6;8(1):16434. doi: 10.1038/s41598-018-34842-5.
Fatigue is a major symptom among patients with Hepatitis B virus (HBV). However, the physiological mechanisms regarding mediate fatigue and the relationships between fatigue, cortisol and cytokines are unclear in patients with HBV. The purpose of this study was to examine the relationships between perceived fatigue, cortisol, and cytokines in Korean patients with HBV. The mean score for overall fatigue was moderate. In linear regression analyses, TNF-α was only significant as a predictor of fatigue. In quantile regression analyses, the cortisol level was significant in the 70, 80, 90 quantiles in the cognitive/mood fatigue subdimension, which correspond to severe levels of fatigue. IL-6 levels were significant in 90 quantile in overall fatigue and in the cognitive/mood fatigue subdimension. Cortisol, IL-6, and TNF- α were related to perceived fatigue in patients with HBV, particularly in the cognitive/mood dimension. This suggests that the fatigue patterns of patients with HBV are related to their mental and mood states and physical responses, such as cortisol and cytokine levels, are correlated with the nature of the fatigue. In the clinic, interventions to manage fatigue in patients with HBV should be developed based on the characteristics of the fatigue.
疲劳是乙型肝炎病毒（HBV）患者的主要症状之一。然而，介导疲劳的生理机制以及疲劳、皮质醇和细胞因子之间的关系在 HBV 患者中尚不清楚。本研究旨在探讨韩国 HBV 患者的感知疲劳、皮质醇和细胞因子之间的关系。总体疲劳的平均得分为中度。在线性回归分析中，TNF-α 仅作为疲劳的预测因子具有统计学意义。在分位数回归分析中，皮质醇水平在认知/情绪疲劳子维度的 70、80、90 分位数上具有统计学意义，这与严重的疲劳水平相对应。IL-6 水平在整体疲劳和认知/情绪疲劳子维度的 90 分位数上具有统计学意义。皮质醇、IL-6 和 TNF-α与 HBV 患者的感知疲劳相关，尤其是在认知/情绪维度。这表明 HBV 患者的疲劳模式与其心理和情绪状态有关，皮质醇和细胞因子水平等生理反应与疲劳的性质相关。在临床上，应根据疲劳的特点为 HBV 患者制定管理疲劳的干预措施。
