探索丝氨酸磷酸酶：从生物化学到生物信息学预测

Craveiro Sarmento Aquiles Sales, de Azevedo Medeiros Lázaro Batista, Agnez-Lima Lucymara Fassarella, Lima Josivan Gomes, de Melo Campos Julliane Tamara Araújo

Laboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Departamento de Medicina Clínica, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.

Int J Cell Biol. 2018 Sep 19;2018:5207608. doi: 10.1155/2018/5207608. eCollection 2018.

Seipin is a nonenzymatic protein encoded by the gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway.

丝氨酸蛋白酶抑制剂（seipin）是一种由该基因编码的非酶蛋白。它与脂肪营养不良和丝氨酸蛋白酶抑制剂病相关。2001年被命名，其所有功能仍远未被理解。因此，我们回顾了大量研究，试图找到一种模式来解释丝氨酸蛋白酶抑制剂表达紊乱常见的特征。同样，本综述展示了这种蛋白质如何似乎具有组织特异性功能。综合来看，我们通过提出一个理论模型来解释丝氨酸蛋白酶抑制剂可能如何参与三酰甘油合成途径来得出结论。