Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390-9041, United States.
Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390-9041, United States.
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1205-1211. doi: 10.1016/j.bbalip.2017.07.003. Epub 2017 Jul 12.
Three proteins have been implicated in the assembly of cytoplasmic lipid droplets: seipin, FIT2, and perilipin. This review examines the current theories of seipin function as well as the evidence for the involvement of all three proteins in droplet biogenesis, and ends with a proposal of how they collaborate to regulate the formation of droplets. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.
seipin、FIT2 和 perilipin。这篇综述考察了 seipin 功能的现有理论，以及所有三种蛋白质参与液滴生物发生的证据，最后提出了它们如何合作来调节液滴形成的建议。本文是由 Rosalind Coleman 和 Matthijs Hesselink 编辑的特刊“脂质滴生物学的最新进展”的一部分。
