Zhao Fangxia, Wan Xunnan, Liang Yan, Liu Weidong, Liu Jianqiang, Pan Ying, Nezamzadeh-Ejhieh Alireza, Li Xiaoxiu
The First Clinical Medical College of Guangdong Medical University, Zhanjiang, 524002, Guangdong Province, China.
Department of Pediatric Gastroenterology, Dongguan Maternal and Child Health Care Hospital, Dongguan Key Laboratory of Children's Digestive and Immune Health, Dongguan, 523000, Guangdong Province, China.
Top Curr Chem (Cham). 2025 Aug 27;383(3):34. doi: 10.1007/s41061-025-00512-0.
Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host-guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure-property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail. Finally, in terms of future perspectives, we discuss emerging opportunities in other delivery systems, personalized medicine platforms, and sustainable environmental applications, underscoring the necessity for cross-disciplinary collaboration between materials science and molecular biology to unlock the full potential of these biohybrid systems.
生物金属有机框架材料（bio-MOFs）已成为一类具有革命性的杂化材料，其特点是具有出色的生物相容性、可编程的生物降解性和主客体分子识别能力。本综述系统地研究了生物金属有机框架材料工程的最新进展，特别关注创新的合成策略以及由其可调孔结构和表面功能所产生的结构-性能关系。详细讨论了生物金属有机框架材料在靶向给药系统、对比增强生物成像以及结合抗炎和抗菌作用的多功能治疗干预中的作用机制基础。最后，就未来展望而言，我们讨论了在其他给药系统、个性化医学平台和可持续环境应用中的新机遇，强调了材料科学与分子生物学之间跨学科合作以释放这些生物杂化系统全部潜力的必要性。
