Xie Yueying, Wang Junjie, Zhao Xiaoya, Zhou Xuli, Nie Xiaohui, Li Chuncheng, Huang Fulian, Yuan Haibin
1 Department of Pathology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
2 Department of Gynaecology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
J Int Med Res. 2018 Dec;46(12):4898-4906. doi: 10.1177/0300060518805600. Epub 2018 Oct 29.
This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk.
PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg's funnel plot and Egger's regression asymmetry test.
Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD -1.379, 95% CI -1.527, -1.231), with high heterogeneity ( I = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD -1.391, 95% CI -1.543, -1.239).
Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.
进行此项荟萃分析以研究血清锌浓度与宫颈癌风险之间的可能关联。
检索PubMed、万方、中国知网和维普数据库中1980年1月至2017年9月发表的相关文章。采用随机效应模型合并结果，并计算合并标准化均数差（SMD）和95%置信区间（CI），以比较宫颈癌患者与对照组的血清锌水平。使用Begg漏斗图和Egger回归不对称检验评估发表偏倚。
本荟萃分析纳入了12篇关于血清锌水平与宫颈癌的文章。合并结果显示，宫颈癌病例的血清锌水平显著低于无宫颈癌的对照组（汇总SMD -1.379，95% CI -1.527，-1.231），异质性较高（I=98.8%）。按地理位置分层的数据分析显示，亚洲人群中血清锌水平与宫颈癌风险之间存在显著关联（汇总SMD -1.391，95% CI -1.543，-1.239）。
较高的血清锌水平可能是亚洲女性宫颈癌的一个保护因素。
