Kartal Ömer, Ataş Erman
Division of Pediatric Hematology and Oncology, Gülhane Training and Research Hospital, 06300 Ankara, Turkey.
Division of Pediatric Oncology, Gülhane Training and Research Hospital, 06300 Ankara, Turkey.
Medicina (Kaunas). 2018 Nov 6;54(5):82. doi: 10.3390/medicina54050082.
Pediatric glioblastoma multiforme is an uncommon and highly mortal brain cancer. New therapeutic treatments are being intensively investigated by researchers in order to extend the survival of patients. The immune checkpoint inhibitor nivolumab in the treatment of pediatric glioblastoma multiforme is currently under review; it is a human immunoglobulin G4 monoclonal antibody that works against the programmed cell death protein 1 receptor, designed to enhance an immunologic reaction against cancer cells. Herein, we describe the first report of a bilateral optic neuritis induced by nivolumab in a grade 4 glioblastoma multiforme patient.
儿童多形性胶质母细胞瘤是一种罕见且致死率很高的脑癌。研究人员正在深入研究新的治疗方法，以延长患者的生存期。免疫检查点抑制剂纳武单抗治疗儿童多形性胶质母细胞瘤目前正在接受审查；它是一种人免疫球蛋白G4单克隆抗体，作用于程序性细胞死亡蛋白1受体，旨在增强针对癌细胞的免疫反应。在此，我们报告首例纳武单抗诱发的4级多形性胶质母细胞瘤患者双侧视神经炎。
