一种用于离心微流控平台的快速微混合器。

A Rapid Micromixer for Centrifugal Microfluidic Platforms.

作者信息

Cai Ziliang, Xiang Jiwen, Chen Hualing, Wang Wanjun

机构信息

Department of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

College of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

出版信息

Micromachines (Basel). 2016 May 10;7(5):89. doi: 10.3390/mi7050089.

DOI:10.3390/mi7050089

PMID:30404263

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6189994/

Abstract

This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator pin installed on the flyball governor system. The flyball governor was used as the transducer to convert the rotary motion into a reciprocating linear motion of the pin pressing against the covering membrane of the mixer chamber. When the rotation speed of the microfluidic disc was periodically altered, the mixing chamber was compressed and released accordingly. In this way, enhanced active mixing can be achieved with much better efficiency in comparison with diffusive mixing.

摘要

本文介绍了一种用于离心微流控平台的创新混合技术，该平台由专门设计的飞球调速器驱动。多层微流控盘采用聚二甲基硅氧烷（PDMS）复制模塑工艺和软光刻技术制造。其工作原理基于弹性覆盖膜与安装在飞球调速器系统上的致动销之间的相互作用。飞球调速器用作换能器，将旋转运动转换为销的往复直线运动，该销压在混合腔的覆盖膜上。当微流控盘的转速周期性变化时，混合腔相应地被压缩和释放。通过这种方式，与扩散混合相比，可以以更高的效率实现增强的主动混合。