Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
mSphere. 2018 Nov 7;3(6):e00221-18. doi: 10.1128/mSphere.00221-18.
Prevention of serious infections in pregnant mothers, newborns, and young infants through immunization during pregnancy and in early life has the potential to further reduce maternal and neonatal morbidity and mortality worldwide. In the past decade, research in this field has advanced substantially, from the understanding of the biology and immunology of pregnancy and early life, to the active development of several candidate vaccines, for which challenges and opportunities for global implementation are under consideration. Experts from academia, industry, regulatory and funding agencies, public health, and international organizations met in Brussels (Belgium) from 10 to 12 September 2017, at the 4th International Neonatal and Maternal Immunization Symposium (INMIS), to review the most relevant advances in maternal and neonatal immunization. The overarching focus of the conference was to identify the path forward to achieve integration of maternal and early life immunization strategies for the successful implementation of vaccines in antenatal care and pediatric programs for reduction of maternal and infant mortality worldwide. This report provides an overview of the proceedings of the 4th International Maternal and Neonatal Immunization Symposium, where presentations focused on the state-of-the-art research on the development and implementation of vaccines given during pregnancy for the protection of mothers and infants.
通过在妊娠期间和生命早期进行免疫接种，预防孕妇、新生儿和婴幼儿发生严重感染，有可能进一步降低全球孕产妇和新生儿发病率和死亡率。在过去十年中，该领域的研究取得了实质性进展，从妊娠和生命早期的生物学和免疫学的理解，到几种候选疫苗的积极开发，目前正在考虑这些疫苗在全球实施的挑战和机遇。学术界、产业界、监管和资助机构、公共卫生和国际组织的专家于 2017 年 9 月 10 日至 12 日在布鲁塞尔（比利时）举行了第四次国际新生儿和孕产妇免疫接种研讨会（INMIS），以审查孕产妇和新生儿免疫接种方面最相关的进展。会议的重点是确定前进的道路，以便整合孕产妇和生命早期免疫接种战略，成功地在产前保健和儿科方案中实施疫苗，从而降低全球孕产妇和婴儿死亡率。本报告概述了第四次国际孕产妇和新生儿免疫接种研讨会的会议记录，会议的介绍重点是关于在妊娠期间接种疫苗以保护母亲和婴儿的最新研究进展和实施情况。
