Pinto Bruna F, Medeiros Nayara I, Fontes-Cal Tereza C M, Naziazeno Isabela M, Correa-Oliveira Rodrigo, Dutra Walderez O, Gomes Juliana A S
Institute of Biological Sciences, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.
René Rachou Institute, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais 30.190-009, Brazil.
Cells. 2018 Nov 7;7(11):200. doi: 10.3390/cells7110200.
Chagas disease, caused by , is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics.
恰加斯病由[病原体名称缺失]引起，是一种潜在威胁生命的热带疾病，在拉丁美洲国家流行，约有800万人受其影响。在疾病的慢性阶段，当临床症状明显时，个体被归类为属于不确定临床类型或心脏和/或消化类型。单核细胞与淋巴细胞之间的关系可能是有助于阐明围绕恰加斯病慢性阶段临床症状的复杂性的一个重要点。共刺激信号对于确定T细胞对抗原的反应强度至关重要。已知这些信号决定后续适应性免疫反应的调节。然而，关于这些分子在恰加斯病中的表达和功能知之甚少。因此，本综述旨在讨论共刺激分子-受体相互作用的主要途径在这种病理中的可能作用，这对于理解疾病动态可能至关重要。
