Liotti F S, Bodo M, Menghini A R, Guerrieri P, Mariucci G, Bruschelli G
Int J Cancer. 1987 Sep 15;40(3):354-7. doi: 10.1002/ijc.2910400312.
Chicken embryo fibroblasts and hepatocytes were studied in the presence of catalase and superoxide dismutase in order to establish whether these enzymes had the capacity to favour cell multiplication as previously shown for in vitro tumour ascites cells (ATP C+). The results indicate that, unlike ATP C+ cells, both fibroblasts and hepatocytes are inhibited in their multiplication by superoxide dismutase. Similar effects are exerted on hepatocytes by catalase, whereas the multiplication of fibroblasts is favoured by high doses of this enzyme. Enzyme determinations revealed high levels of catalase and superoxide dismutase in hepatocytes, whereas both enzymes were poor in fibroblasts and ATP C+.
为了确定过氧化氢酶和超氧化物歧化酶是否具有促进细胞增殖的能力，就像之前在体外肿瘤腹水细胞（ATP C+）中所显示的那样，对鸡胚成纤维细胞和肝细胞进行了研究。结果表明，与ATP C+细胞不同，超氧化物歧化酶抑制成纤维细胞和肝细胞的增殖。过氧化氢酶对肝细胞也有类似作用，而高剂量的该酶则促进成纤维细胞的增殖。酶活性测定显示，肝细胞中过氧化氢酶和超氧化物歧化酶水平较高，而成纤维细胞和ATP C+中这两种酶的含量都很低。
