Papalazarou Vassilis, Salmeron-Sanchez Manuel, Machesky Laura M
CRUK Beatson Institute for Cancer Research and Institute of cancer Sciences, University of Glasgow, Garscube Campus, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.
The Centre for the Cellular Microenvironment, University of Glasgow, Glasgow, G12 8QQ, UK.
Biophys Rev. 2018 Dec;10(6):1695-1711. doi: 10.1007/s12551-018-0466-8. Epub 2018 Nov 8.
Mechanosensing is increasingly recognised as important for tumour progression. Tumours become stiff and the forces that normally balance in the healthy organism break down and become imbalanced, leading to increases in migration, invasion and metastatic dissemination. Here, we review recent advances in our understanding of how extracellular matrix properties, such as stiffness, viscoelasticity and architecture control cell behaviour. In addition, we discuss how the tumour microenvironment can be modelled in vitro, capturing these mechanical aspects, to better understand and develop therapies against tumour spread. We argue that by gaining a better understanding of the microenvironment and the mechanical forces that govern tumour dynamics, we can make advances in combatting cancer dormancy, recurrence and metastasis.
机械传感对于肿瘤进展的重要性日益得到认可。肿瘤会变得僵硬，而在健康机体中通常保持平衡的力会瓦解并失衡，导致迁移、侵袭和转移扩散增加。在此，我们综述了近期在理解细胞外基质特性（如硬度、粘弹性和结构）如何控制细胞行为方面取得的进展。此外，我们还讨论了如何在体外模拟肿瘤微环境，捕捉这些力学方面，以更好地理解并开发针对肿瘤扩散的治疗方法。我们认为，通过更好地理解微环境以及控制肿瘤动态的力学力，我们能够在对抗癌症休眠、复发和转移方面取得进展。
